Sustainable synthesis of pyrazoles using alcohols as the primary feedstock by an iron catalyzed tandem C-C and C-N coupling approach was written by Mondal, Rakesh;Guin, Amit Kumar;Pal, Subhasree;Mondal, Sucheta;Paul, Nanda D.. And the article was included in Organic Chemistry Frontiers in 2022.Category: benzothiophene This article mentions the following:
Authors report two new efficient iron-catalyzed synthetic strategies for multicomponent synthesis of tri-substituted pyrazoles using biomass-derived alcs. as the primary feedstock. A well-defined, bench stable, and easy to prepare Fe(II)-catalyst bearing a tridentate pincer 2-(phenyldiazenyl)-1,10-phenanthroline was used as the catalyst. A wide variety of tri-substituted pyrazoles were prepared via dehydrogenative coupling of alcs., and aryl hydrazines with secondary alcs. and alkynes, resp. These methods eliminate the potential use of any pre-functionalized starting materials, noble metal catalysts, oxidants, or additives producing various substituted pyrazoles in moderate to good isolated yields via sequential C-C and C-N bond formation. A series of control experiments and spectroscopic studies were performed to understand the plausible mechanism of these multicomponent reactions. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Category: benzothiophene).
2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Category: benzothiophene
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem