An approach for the synthesis of 2-aryl-3-sulfonyl substituted quinolines through an electrochemical cascade annulation pathway was written by Ma, Qiang;Li, Ming;Chen, Zhuo;Ni, Shao-Fei;Wright, James S.;Wen, Li-Rong;Zhang, Lin-Bao. And the article was included in Green Chemistry in 2022.Application of 4298-52-6 This article mentions the following:
An electrochem. protocol for the synthesis of 2,3-disubstituted quinolines I (R = H, Me, Br, Cl, etc.; R1 = H, Me, F; R2 = Ph, 2-chlorophenyl, thiophen-2-yl, etc.; R3 = Ph, 3-bromophenyl, 4-cyclohexylphenyl, etc.) by reacting benzoxazinones II with arylsulfonyl hydrazides R3S(O)2NHNH2 was established under simple and mild conditions (room temperature and an undivided cell). The methodol. does not require noble catalysts or external oxidants, providing a green and mild pathway for de novo synthesis of functional quinolines I with excellent regioselectivity. Moreover, the method tolerated a variety of functional groups. Notably, the scaled-up experiment and follow-up procedures demonstrate the practicality of electrochem. synthesis. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Application of 4298-52-6).
2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Application of 4298-52-6
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem