A novel type of radical-addition-induced β-fragmentation and ensuing remote functionalization was written by Li, Xin;Shui, Yang;Shen, Pingkang;Wang, Yi-Peng;Zhang, Chi;Feng, Chao. And the article was included in Chem in 2022.Computed Properties of C6H4S This article mentions the following:
Herein, authors report a strategically novel synthetic protocol for the efficient construction of α-trifluoromethyl-β-amino ketone and α-sulfonyl-β-amino ketone derivatives 4-Isoxazoline is introduced, for the first time, as a class of effective nucleophilic SOMOphile (SOMO, single occupied MO) that readily reacts with electrophilic open-shell species such as trifluoromethyl radical and sulfonyl radical through a cascade of the homolytic addition/β-fragmentation manifold. The underlying polar effect is ascribed as the dominant factor that guarantees the cascade process both in high reaction efficiency and regioselectivity. This protocol is characterized by its mild reaction conditions and broad substrate scope, whereas the ease of acquiring enantiopure α-polyfluoroalkyl-β-amino ketone derivatives with readily accessed chiral 4-isoxazolines adds extra merit to this reaction. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Computed Properties of C6H4S).
2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Computed Properties of C6H4S
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem