Modular Synthesis of Enantioenriched α-Chiral Homoallylic Amidines Enabled by Relay Ir/Cu Catalysis was written by Li, Ting-Peng;Li, Ren-Sha;Hu, Wei;Xie, Jia-Xin;Xu, Minghui;Feng, Chun;Ni, Hai-Liang;Yu, Wen-Hao;Hu, Ping;Wang, Bi-Qin;Cao, Peng. And the article was included in Organic Letters in 2022.Electric Literature of C6H4S This article mentions the following:
The cascade of Ir-catalyzed enantioselective allylic amination and Cu-catalyzed alkyne-azide cycloaddition was designed for the asym. synthesis of homoallylic amidines, e.g., I. The nucleophilic addition of an in situ-generated enantioenriched tertiary allylamine to a ketenimine intermediate triggers a rapid and stereospecific zwitterionic aza-Claisen rearrangement in a 1,3-chiral transfer manner. The approach allowed modular access to enantioenriched α-chiral homoallylic amidines in high yields with a high level of enantiomeric purity. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Electric Literature of C6H4S).
2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Electric Literature of C6H4S
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem