Inhibitors of 15-Prostaglandin Dehydrogenase To Potentiate Tissue Repair was written by Antczak, Monika I.;Zhang, Yongyou;Wang, Changguang;Doran, Jennifer;Naidoo, Jacinth;Voruganti, Sukesh;Williams, Noelle S.;Markowitz, Sanford D.;Ready, Joseph M.. And the article was included in Journal of Medicinal Chemistry in 2017.SDS of cas: 3988-77-0 This article mentions the following:
The enzyme 15-prostaglandin dehydrogenase (15-PGDH) catalyzes the first step in the degradation of prostaglandins including PGE2. It is a neg. regulator of tissue repair and regeneration in multiple organs. Accordingly, inhibitors of 15-PGDH are anticipated to elevate in vivo levels of PGE2 and to promote healing and tissue regeneration. The small mol. SW033291 (1) inhibits 15-PGDH with Ki = 0.1 nM in vitro, doubles PGE2 levels in vivo, and shows efficacy in mouse models of recovery from bone marrow transplantation, ulcerative colitis, and partial hepatectomy. Here we describe optimized variants of 1 with improved solubility, druglike properties, and in vivo activity. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0SDS of cas: 3988-77-0).
3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.SDS of cas: 3988-77-0
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem