Synthesis and evaluation of small libraries of triazolylmethoxy chalcones, flavanones and 2-aminopyrimidines as inhibitors of mycobacterial FAS-II and PknG was written by Anand, Namrata;Singh, Priyanka;Sharma, Anindra;Tiwari, Sameer;Singh, Vandana;Singh, Diwakar K.;Srivastava, Kishore K.;Singh, B. N.;Tripathi, Rama Pati. And the article was included in Bioorganic & Medicinal Chemistry in 2012.Related Products of 329221-38-7 This article mentions the following:
A synthetic strategy to access small libraries of triazolylmethoxy chalcones 4{1-20}, triazolylmethoxy flavanones 5{1-10} and triazolylmethoxy aminopyrimidines 6{1-17} from a common substrate 4-propargyloxy-2-hydroxy acetophenone using a set of different reactions has been developed. The chalcones and flavanones were screened against mycobacterial FAS-II pathway using a recombinant mycobacterial strain, against which the most potent compound showed ∼88% inhibition in bacterial growth and substantially induction of reporter gene activity at 100 μM concentration The triazolylmethoxy aminopyrimdines were screened against PknG of Mycobacterium tuberculosis displaying moderate to good activity (23-53% inhibition at 100 μM), comparable to the action of a standard inhibitor. In the experiment, the researchers used many compounds, for example, Ax20017 (cas: 329221-38-7Related Products of 329221-38-7).
Ax20017 (cas: 329221-38-7) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Related Products of 329221-38-7
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem