Day: February 22, 2023

A rapid and sensitive procedure for the quantitative determination of plasma amino acids was written by Griffin, Martin;Price, Susan J.;Palmer, Trevor. And the article was included in Clinica Chimica Acta in 1982.Product Details of 32595-59-8 This article mentions the following:

Amino acids were determined by precolumn derivatization with o-phthalaldehyde and 2-mercaptoethanol and separation by reversed-phase high-performance liquid chromatog. The stationary phase was Zorbax C₈, and the mobile phase was a gradient of KOAc (0.02M, pH 5.5) containing 1% THF in MeOH:THF (99:1). Thirty amino acids and amines were separated in 27.5 min, with a lower detection limit of <1 pmol. In the experiment, the researchers used many compounds, for example, 2-Amino-3-hydroxy-3-(thiophen-2-yl)propanoic acid (cas: 32595-59-8Product Details of 32595-59-8).

2-Amino-3-hydroxy-3-(thiophen-2-yl)propanoic acid (cas: 32595-59-8) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Product Details of 32595-59-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Magnetic-covalent organic polymer solid-phase extraction coupled with high-performance liquid chromatography for the sensitive determination of fluorescent whitening agents in cosmetics was written by Xia, Ling;Chen, Xiaoman;Xiao, Xiaohua;Li, Gongke. And the article was included in Journal of Separation Science in 2018.Electric Literature of C26H26N2O2S This article mentions the following:

Magnetic solid-phase extraction is a powerful sample preparation tool. Combined with covalent organic polymers, this technique permits an excellent extraction performance. We present a sensitive, efficient, and easy operating magnetic- covalent organic polymer solid-phase extraction method. By using the magnetic covalent organic polymer nanoparticles yielded by a one-pot reaction, five fluorescent whitening agents were successfully preconcd. and separated The saturated extraction amounts of the magnetic covalent organic polymer nanoparticles for the five fluorescent whitening agents were in the range of 97-155 nmol/mg. Coupled with high-performance liquid chromatog., the limit of detection of the fluorescent whitening agent was improved by at least an order of magnitude compared to current literature records. Under the optimal conditions, the linear ranges of these five fluorescent whitening agents were up to 0.5-100 ng/L, the limit of detection was as low as 0.1 ng/L, and the recoveries were in the range of 78.2-105% with relative standard deviations lower than 5.5%. Meanwhile, a trace level of 7-diethylamino-4-methylcoumarin was found in a typical cosmetic sample by using this magnetic-covalent organic polymer solid-phase extraction method when coupling with high-performance liquid chromatog. Moreover, this sensitive, efficient, and easy operating sample preparation method can be extended to anal. of other analytes that have a π-π conjugated structure. In the experiment, the researchers used many compounds, for example, 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5Electric Literature of C26H26N2O2S).

2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Electric Literature of C26H26N2O2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Application of Polyphosphoric Acid-Mediated Acyl Migration for Regiospecific Synthesis of Diverse 2-Acylpyrroles from Chalcones was written by Kumar, Togiti Uday;Thigulla, Yadagiri;Rangan, Krishnan;Bhattacharya, Anupam. And the article was included in Journal of Heterocyclic Chemistry in 2019.HPLC of Formula: 3988-77-0 This article mentions the following:

A metal-free approach for the synthesis of 2-acylpyrroles was reported. Synthesis of the target mol. started from chalcones and carried out in two steps. Initial step involved the conversion of chalcones to corresponding 4-substituted-3-acylpyrroles by reaction with TosMIC. In the subsequent step, target mols. were obtained in modest to good yields by polyphosphoric acid-mediated acyl rearrangement of 3-acylpyrroles to their 2-acyl congeners. The crucial final step was amenable to diverse substitutions on pyrrole ring. Preliminary experiment for the determination of mechanism indicated the involvement of acylium ion. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0HPLC of Formula: 3988-77-0).

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.HPLC of Formula: 3988-77-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Boosting the Enantioselectivity of Conjugate Borylation of α,β-Disubstituted Cyclobutenones with Monooxides of Chiral C₂-Symmetric Bis(phosphine) Ligands was written by Cui, Ming;Zhao, Zhi-Yuan;Oestreich, Martin. And the article was included in Chemistry – A European Journal in 2022.Related Products of 67237-53-0 This article mentions the following:

Chiral bis(phosphine) monooxides (BPMOs) derived from C₂-sym. bis(phosphines) have been found to induce superior levels of enantioselection in copper-catalyzed conjugate borylation of α,β-disubstituted cyclobutenones. More precisely, enantiomeric excesses as well as chem. yields are exceedingly high with (R,R)-Bozphos as the chiral ligand while these values are low with parent (R,R)-Me-Duphos. A similar yet less pronounced effect was seen in the corresponding 1,6-addition to para-quinone methides. In the experiment, the researchers used many compounds, for example, 3-Ethynylthiophene (cas: 67237-53-0Related Products of 67237-53-0).

3-Ethynylthiophene (cas: 67237-53-0) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is also used in the manufacturing of dyes such as thioindigo.Related Products of 67237-53-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

An approach for the synthesis of 2-aryl-3-sulfonyl substituted quinolines through an electrochemical cascade annulation pathway was written by Ma, Qiang;Li, Ming;Chen, Zhuo;Ni, Shao-Fei;Wright, James S.;Wen, Li-Rong;Zhang, Lin-Bao. And the article was included in Green Chemistry in 2022.Application of 4298-52-6 This article mentions the following:

An electrochem. protocol for the synthesis of 2,3-disubstituted quinolines I (R = H, Me, Br, Cl, etc.; R¹ = H, Me, F; R² = Ph, 2-chlorophenyl, thiophen-2-yl, etc.; R³ = Ph, 3-bromophenyl, 4-cyclohexylphenyl, etc.) by reacting benzoxazinones II with arylsulfonyl hydrazides R³S(O)₂NHNH₂ was established under simple and mild conditions (room temperature and an undivided cell). The methodol. does not require noble catalysts or external oxidants, providing a green and mild pathway for de novo synthesis of functional quinolines I with excellent regioselectivity. Moreover, the method tolerated a variety of functional groups. Notably, the scaled-up experiment and follow-up procedures demonstrate the practicality of electrochem. synthesis. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Application of 4298-52-6).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Application of 4298-52-6

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Cobalt-catalyzed branched selective hydroallylation of terminal alkynes was written by Chen, Jieping;Ying, Jiale;Lu, Zhan. And the article was included in Nature Communications in 2022.Related Products of 4298-52-6 This article mentions the following:

Here, authors reported a cobalt-hydride-catalyzed Markovnikov-type hydroallylation of terminal alkynes with allylic electrophile to access valuable and branched skipped dienes (1,4-dienes) with good regioselectivity. This operationally simple protocol exhibits excellent functional group tolerance and exceptional substrate scope. The reactions could be carried out in gram-scale with TON (turn over number) up to 1160, and the products could be easily derivatized. The preliminary mechanism of electrophilic allylation of α-selective cobalt alkenyl intermediate was proposed based on deuterium labeling experiment and kinetic studies. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Related Products of 4298-52-6).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is also used in the manufacturing of dyes such as thioindigo.Related Products of 4298-52-6

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Nonplanar Butterfly-Shaped π-Expanded Pyrrolopyrroles was written by Krzeszewski, Maciej;Kodama, Takuya;Espinoza, Eli M.;Vullev, Valentine I.;Kubo, Takashi;Gryko, Daniel T.. And the article was included in Chemistry – A European Journal in 2016.Recommanded Product: Benzo[b]thiophen-3-ylboronic acid This article mentions the following:

Large aza-analogs of curved polycyclic aromatic hydrocarbons with a double-helicene structure present unique features for mol. photonics. We present the preparation and characterization of three such structures. The synthesis of these heterocyclic nanographenes involves only a few high-yield steps that use readily available starting materials. X-ray anal. revealed that each of these new dyes has three conformational isomers: one diastereoisomer in a meso form and two enantiomers in twisted forms [(P,P)] and [(M,M)]. The low energy barriers between the conformers, however, prevent their separation by using chiral HPLC, and the NMR spectra show only one set of signals for each of these curved compounds D. functional theory (DFT) calculations quantify the small energy difference and the small energy barriers between the chiral and meso forms, which fully supports the exptl. results. Their optical absorption lacks any sensitivity to the solvent environment, whereas their fluorescence features exhibit pronounced solvatochromism. This rarely observed solvatofluorochromism of centrosym. mols. without either electron-withdrawing groups or -donating substituents was probed by using time-resolved spectroscopy. These studies suggest that, similar to 9,9′-bianthryl, the nonpolar locally excited state shows negligible solvatochromism, whereas the charge-transfer state is sensitive to solvent polarity. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6Recommanded Product: Benzo[b]thiophen-3-ylboronic acid).

Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Recommanded Product: Benzo[b]thiophen-3-ylboronic acid

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Chemoselective electrocatalytic hydroboration of alkynes with pinacolborane was written by Qiu, Hui;Lv, Kang;Qu, Haoqi;Zhang, Xuguang;Yuan, Taoyue;Yao, Weiwei;Xue, Fei;Ma, Mengtao. And the article was included in Journal of Molecular Structure in 2022.COA of Formula: C6H4S This article mentions the following:

A green and sustainable non-catalytic electrochem. hydroboration of various alkynes ArCCH with HBpin has been reported for the first time, giving arylvinylboronates (E)-ArCH:CHBpin. Under catalyst-free and additive-free mild reaction conditions the corresponding alkenyl boronic esters were obtained in good to excellent yields within 30 min at room temperature A plausible reaction mechanism was proposed based on the corresponding experiments In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6COA of Formula: C6H4S).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.COA of Formula: C6H4S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Carbon disulfide formation in papaya under conditions of dithiocarbamate residue analysis was written by Abakerli, R. B.;Sparrapan, R.;Sawaya, A. C. H. F.;Eberlin, M. N.;Jara, J. L. P.;Rodrigues, N. R.;Fay, E. F.;Luiz, A. J. B.;Galvao, T. D. L.;Martins, D. dos S.;Yamanishi, O. K.;Toledo, H. H. B.. And the article was included in Food Chemistry in 2015.Synthetic Route of C6H8S This article mentions the following:

Golden, Sunrise Solo and Tainung cultivars of papaya were found to release CS₂ when submitted to exptl. conditions of dithiocarbamate residue anal. Three common anal. methods were used to quantitate CS₂; one spectrophotometric method and two chromatog. methods. All three methods gave pos. CS₂ results for all three papaya varieties. Other endogenous compounds present in isooctane extracts of papaya fractions detected via gas chromatog. (GC/ITD) using electron ionization (EI) were: carbonyl sulfide, di-Me sulfide, carbon disulfide, 2-methylthiophene, 3-methylthiophene, 2-ethylthiophene, 3-ethylthiophene, benzylisothiocyanate, benzylthiocyanate, and benzonitrile. Control samples were obtained from papaya plantations cultivated in exptl. areas, in which no treatment with fungicides of the dithiocarbamate group was applied. Endogenous CS₂ levels were compared with true dithiocarbamate residues measured in papaya samples from the field trials following applications of mancozeb fungicide. Three days after application, true dithiocarbamate residues, measured by the procedure with isooctane partitioning and GC-ITD, were at the average level of 2 mg kg^-1. In the experiment, the researchers used many compounds, for example, 3-Ethylthiophene (cas: 1795-01-3Synthetic Route of C6H8S).

3-Ethylthiophene (cas: 1795-01-3) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Synthetic Route of C6H8S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Green synthesis, molecular docking and pharmacological evaluation of new triazolo-thiadiazepinylcoumarin derivatives as sedative-hypnotic scaffold was written by Gomha, Sobhi M.;Abdel-aziz, Hassan M.;Abolibda, Tariq Z.;Hassan, Shaimaa A.;Abdalla, Mohamed M.. And the article was included in Journal of Heterocyclic Chemistry in 2020.Electric Literature of C13H10OS This article mentions the following:

4-Amino-5-mercapto-4H-1,2,4-triazole was used as a key intermediate for the preparation of 1,2,4-triazolo[3,4-b][1,3,4]thiadiazepine derivatives I [X = H, Me, OMe, Cl], II [Y = CN, COOEt; Ar = 2-furanyl, Ph, 4-methylphenyl, 4-chlorophenyl] and III via reactions with the appropriate chalcones, α,β-unsaturated carbonitrile derivatives resp. The identity of the synthesized compounds was elucidated via their spectral data and elemental anal. Moreover, the sedative-hypnotic activity of the newly synthesized compounds were evaluated and showed excellent activities especially compounds II [Y = CN, Ar = 4-methylphenyl; Y = COOEt, Ar = 4-methylphenyl] and III. Also, their structure activity relationship was clearly demonstrated and showed that the electron-donating groups enhance activities while electron-withdrawing groups decrease activities. The mol. docking of the most active derivative III against γ-amino butyric acid (GABA) receptor was performed by the MOE 2014 program. The acquired outcomes demonstrated that the most active compounds could be a helpful model for future structure, adjustment and examination to build more active analogs. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Electric Literature of C13H10OS).

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Electric Literature of C13H10OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem