Facile Synthesis of Substituted 4-Alkoxy-2-oxazolines and Exploration of the Reaction Mechanism was written by Zhu, Jianming;Li, Xiaolong;Wang, Guimin;Li, Bo;Xu, Zhijian;Tian, Shikai;Hall, Adrian;Shen, Jingshan;Shi, Jiye;Zhu, Weiliang. And the article was included in Synthesis in 2016.Application In Synthesis of Benzo[b]thiophene-2-carbonitrile This article mentions the following:
Substituted 4-alkoxy-2-oxazolines, e.g., I [R = H, (2,3-MeO)2, 4-F, etc.], have been synthesized via the reaction of nitriles with beta-hydroxyacetals promoted by trifluoromethanesulfonic acid. The reaction is proposed to be initiated by the protonation of the acetals to produce carbocations that are then attacked by nitrogen atom of the nitriles, followed by an intramol. cyclization reaction to form the 4-alkoxy-2-oxazolines. The proposed reaction mechanism has been validated by quantum chem. calculations, key intermediate synthesis, and NMR spectra. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Application In Synthesis of Benzo[b]thiophene-2-carbonitrile).
Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Application In Synthesis of Benzo[b]thiophene-2-carbonitrile
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem