New catalytic properties of iron complexes. Dehydration of amides to nitriles was written by Zhou, Shaolin;Addis, Daniele;Das, Shoubhik;Junge, Kathrin;Beller, Matthias. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2009.Application In Synthesis of Benzo[b]thiophene-2-carbonitrile This article mentions the following:
Various iron carbonyl clusters such as Fe2(CO)9 or [Et3NH][HFe3(CO)11] catalyzed the dehydration of amides into the corresponding nitriles in the presence of silanes in high yields. This novel protocol showed good functional group tolerance and wide substrate scope. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Application In Synthesis of Benzo[b]thiophene-2-carbonitrile).
Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Application In Synthesis of Benzo[b]thiophene-2-carbonitrile
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem