Nickel-catalyzed and Li-mediated regiospecific C-H arylation of benzothiophenes was written by Mohr, Yorck;Hisler, Gaelle;Grousset, Leonie;Roux, Yoann;Quadrelli, Elsje Alessandra;Wisser, Florian M.;Canivet, Jerome. And the article was included in Green Chemistry in 2020.Safety of 6-Methoxybenzo[b]thiophene This article mentions the following:
A nickel-based catalytic system for the regiospecific C2-H arylation of benzothiophenes with aryl iodides to afford 2-aryl benzothiophenes I [R1 = H, 5-Me, 5-F, etc.; Ar = Ph, 4-FC6H4, 1-naphthyl, etc.] was established. NiCl2(bpy) was used as a catalyst in combination with LiHMDS as a base in dioxane. The catalytic system was applicable to a variety of functionalized benzothiophenes, as well as other heteroarenes including thiophene, benzodithiophene, benzofuran and selenophene in combination with iodo aryl electrophiles. The role of LiHMDS as a uniquely potent base and a postulated mechanism were discussed. The applicability of this system was finally demonstrated for the synthesis of an intermediate of an active pharmaceutical ingredient. In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4Safety of 6-Methoxybenzo[b]thiophene).
6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Safety of 6-Methoxybenzo[b]thiophene
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem