One-Pot Transformation of Carboxylic Acids into Nitriles was written by Miyagi, Kotaro;Moriyama, Katsuhiko;Togo, Hideo. And the article was included in European Journal of Organic Chemistry in 2013.Quality Control of Benzo[b]thiophene-2-carbonitrile This article mentions the following:
A variety of aromatic and aliphatic carboxylic acids were smoothly converted into the corresponding nitriles in good yields in a one-pot procedure by treatment with Et iodide/K2CO3/18-crown-6, followed by sodium diisobutyl-tert-butoxyaluminum hydride (SDBBA-H), and finally treatment with mol. iodine or 1,3-diiodo-5,5-dimethylhydantoin (DIH), and aqueous ammonia. This method is useful for the conversion of various aromatic and aliphatic carboxylic acids into the corresponding nitriles in a one-pot procedure. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Quality Control of Benzo[b]thiophene-2-carbonitrile).
Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Quality Control of Benzo[b]thiophene-2-carbonitrile
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem