Day: February 10, 2023

Enantioselective Hydroarylation or Hydroalkenylation of Benzo[b]thiophene 1,1-Dioxides with Organoboranes was written by Hu, Fangdong;Jia, Jie;Li, Ximing;Xia, Ying. And the article was included in Organic Letters in 2021.Recommanded Product: 6-Methoxybenzo[b]thiophene This article mentions the following:

An efficient protocol for the asym. hydroarylation and hydroalkenylation of benzo[b]thiophene 1,1-dioxides with organoboranes was developed. The combination of a rhodium(I) precatalyst and a chiral diene ligand constituted the catalytic system, which enabled the facile synthesis of 2,3-dihydrobenzo[b]thiophene 1,1-dioxides I [R = H, 5-Me, 7-Me, etc.; R¹ = H, Me, Et, i-Pr; Ar = Ph, 2-naphthyl, 3-thienyl, (E)-styryl, etc.] in good yields with high enantioselectivities. The merging of this asym. hydroarylation with the downstream alkylations delivered 2,3-dihydrobenzo[b]thiophene 1,1-dioxides that contain two continuous quaternary stereocenters with high enantioselectivities in a diastereodivergent manner. In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4Recommanded Product: 6-Methoxybenzo[b]thiophene).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Recommanded Product: 6-Methoxybenzo[b]thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Facile Synthesis of Substituted 4-Alkoxy-2-oxazolines and Exploration of the Reaction Mechanism was written by Zhu, Jianming;Li, Xiaolong;Wang, Guimin;Li, Bo;Xu, Zhijian;Tian, Shikai;Hall, Adrian;Shen, Jingshan;Shi, Jiye;Zhu, Weiliang. And the article was included in Synthesis in 2016.Application In Synthesis of Benzo[b]thiophene-2-carbonitrile This article mentions the following:

Substituted 4-alkoxy-2-oxazolines, e.g., I [R = H, (2,3-MeO)₂, 4-F, etc.], have been synthesized via the reaction of nitriles with beta-hydroxyacetals promoted by trifluoromethanesulfonic acid. The reaction is proposed to be initiated by the protonation of the acetals to produce carbocations that are then attacked by nitrogen atom of the nitriles, followed by an intramol. cyclization reaction to form the 4-alkoxy-2-oxazolines. The proposed reaction mechanism has been validated by quantum chem. calculations, key intermediate synthesis, and NMR spectra. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Application In Synthesis of Benzo[b]thiophene-2-carbonitrile).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Application In Synthesis of Benzo[b]thiophene-2-carbonitrile

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Reaction of halothianaphthenes with metal amides was written by Reinecke, Manfred G.;Hollingworth, T. A.. And the article was included in Journal of Organic Chemistry in 1972.SDS of cas: 6287-82-7 This article mentions the following:

2-Halothianaphthenes react with metal amides in liquid NH3 to give the 3-isomers which are stable under the reaction conditions. No amines or polyhalo compounds were detected. 2,3-Dibromothianaphthene is converted to 3-bromothianaphthene either with or without added thianaphthene. The former instance suggests an intermol. transhalogenation involving carbanions and the latter a dehalogenation via BrNH2. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7SDS of cas: 6287-82-7).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is also used in the manufacturing of dyes such as thioindigo.SDS of cas: 6287-82-7

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Simple one-pot conversion of alcohols into nitriles was written by Shimojo, Hiroyuki;Moriyama, Katsuhiko;Togo, Hideo. And the article was included in Synthesis in 2013.COA of Formula: C9H5NS This article mentions the following:

Various benzylic and primary alcs. were efficiently converted into the corresponding nitriles in good yields at room temperature by treatment with Me₃COCl, I₂, or 1,3-diiodo-5,5-dimethylhydantoin in the presence of TEMPO, followed by treatment with I₂ and aqueous NH₃. The nitriles were obtained in good yields and high purities simply by extraction of the reaction mixture with CHCl₃ and subsequent removal of the solvent. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9COA of Formula: C9H5NS).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.COA of Formula: C9H5NS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Thermally-stable 2,3-diphenylated benzotiophene containing host materials for red phosphorescent organic light-emitting diodes was written by Jeon, Joon Ho;Lee, Nam-Jin;Lee, Ji-Hoon;Suh, Min Chul. And the article was included in Dyes and Pigments in 2014.Related Products of 6287-82-7 This article mentions the following:

This study reports a series of benzo[b]thiophene (BT) derivatives with good electronic properties as host materials for red phosphorescent organic light-emitting diodes (PHOLEDs). We applied thermally-stable materials for red PHOLEDs which contain BT and carbazole moieties which also provide a good charge transport ability, as well as a good charge confinement effect (T₁ > 2.25 eV). To control the appropriate charge transporting ability, two different structures having one or two carbazole units connected to the single BT moiety were prepared Using this approach, we found that the material with a single carbazole and a single BT unit showed the best current efficiency and external quantum efficiency (up to 23.6 cd/A and 12.8%, resp.). The results of the experiment also suggest that BT could be used as an electron-transporting unit when utilized with carbazole moiety, although it has previously been utilized as a p-type material. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Related Products of 6287-82-7).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Related Products of 6287-82-7

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis and application of 1-(2-methyl-3-benzothienyl)-2-[3-methyl-2-thienyl]perfluorocyclopentene was written by Li, Gang;Liu, Gang;Pu, Shouzhi. And the article was included in Advanced Materials Research (Durnten-Zurich, Switzerland) in 2015.HPLC of Formula: 10243-15-9 This article mentions the following:

A novel unsym. photochromic diarylethene compound 1-(2-methyl-3-benzothienyl)-2-[3-methyl-2-thienyl]perfluorocyclopentene (I) was designed and constructed successfully. Its optoelectronic properties have been discussed systematically, such as photochromic, fluorescence switch, kinetics experiments in hexane solution and PMMA. The consequences showed that this compound exhibited good reversible photochromism. The maxima absorption of compound closed-ring isomer is 468 nm. Upon irradiation with 297 nm UV light, its fluorescence intensity decreased along with the photochromism from open-ring isomers to closed-ring isomers upon irradiation with 297 nm UV light. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9HPLC of Formula: 10243-15-9).

3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is also used in the manufacturing of dyes such as thioindigo.HPLC of Formula: 10243-15-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Room-Temperature Hydrodehalogenation of Halogenated Heteropentalenes with One or Two Heteroatoms was written by Chelucci, Giorgio;Baldino, Salvatore;Ruiu, Andrea. And the article was included in Journal of Organic Chemistry in 2012.Recommanded Product: 2,3-Dibromobenzo[b]thiophene This article mentions the following:

The pair NaBH₄-TMEDA as a hydride source and catalytic PdCl₂(dppf) in THF prove to be an efficient system for the hydrodehalogenation of bromo(chloro)-heteropentalenes with one or two heteroatoms, while Pd(OAc)₂/PPh₃ is able to reduce reactive haloheteropentalenes, and PdCl₂(tbpf) allows the removal of the 2-chlorine from a thiophene ring. The reaction conditions tolerate various functional groups, allowing highly chemoselective reactions in the presence of halide, ester, alkyne, alkene, and nitrile substituents and also showing good efficiency in the regioselective hydrodehalogenation of a variety of polyhalogenated substrates. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Recommanded Product: 2,3-Dibromobenzo[b]thiophene).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Recommanded Product: 2,3-Dibromobenzo[b]thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Sonogashira reaction of 5-substituted 3-(prop-2-yn-1-yl)oxolan-2-ones was written by Ghochikyan, T. V.;Samvelyan, M. A.;Galstyan, A. S.;Gevorgyan, A.;Vardanyan, G.;Grigoryan, T.;Langer, P.. And the article was included in Russian Journal of Organic Chemistry in 2017.Formula: C8H4Br2S This article mentions the following:

Palladium-catalyzed cross-coupling of 5-methyl- and 5,5-dimethyl-3-(prop-2-yn-1-yl)oxolan-2-ones with dihaloarenes (dihaloheteroarenes) gave mixtures of the corresponding mono-coupling products I (R = H, Me; R¹ = 2-BrC₆H₄, 4-Br-2-F₃CC₆H₃, 4-bromothiophen-3-yl, etc.) and bis-coupling products II (X = 1,3-C₆H₄, 2-CF₃-1,4-C₆H₃, thiophene-3,5-diyl, etc.). The latter can be obtained as the major products by variation of the catalytic system. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Formula: C8H4Br2S).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Formula: C8H4Br2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Cyanation of aromatic/vinylic boronic acids with α-cyanoacetates was written by Wang, Xian-Jin;Zhang, Song-Lin. And the article was included in New Journal of Chemistry in 2017.HPLC of Formula: 55219-11-9 This article mentions the following:

A friendly protocol was reported to achieve cyanation of aromatic and vinylic boronic acids using nontoxic and readily available α-cyanoacetates as a cyano source under aerobic conditions. Many aryl/vinyl boronic acids (as well as some iodides and bromides) were amenable substrates to give aryl nitriles ArCN [Ar = 4-MeOC₆H₄, 3-quinolinyl, 2-benzothienyl, etc.] and acrylonitriles I [R¹ = H, Ph; R² = Ph, 4-MeOC₆H₄, 4-BrC₆H₄; R³ = H, Ph]. This cyanation method provided a safe and operationally convenient alternative to traditional ones requiring toxic cyanide salts. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9HPLC of Formula: 55219-11-9).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.HPLC of Formula: 55219-11-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Rh-Catalyzed Dehydrogenative Cyclization Leading to Benzosilolothiophene Derivatives via Si-H/C-H Bond Cleavage was written by Mitsudo, Koichi;Tanaka, Seiichi;Isobuchi, Ryota;Inada, Tomohiro;Mandai, Hiroki;Korenaga, Toshinobu;Wakamiya, Atsushi;Murata, Yasujiro;Suga, Seiji. And the article was included in Organic Letters in 2017.Computed Properties of C8H4Br2S This article mentions the following:

Straightforward syntheses leading to π-extended benzosilolothiophene (BST) derivatives by Rh-catalyzed dehydrogenative cyclization reactions were developed. Electron-deficient ligands were effective for the reactions, and dppe-F₂₀ gave the best result. This method could be applied to the synthesis of highly π-extended ladder-type BST derivatives, which exhibited fluorescence. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Computed Properties of C8H4Br2S).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is also used in the manufacturing of dyes such as thioindigo.Computed Properties of C8H4Br2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem