Chloro-oxime derivatives as novel small molecule chaperone amplifiers was written by Zhou, Yuefen;Vu, Khang;Chen, Yongsheng;Pham, John;Brady, Thomas;Liu, Gang;Chen, Jinhua;Nam, Joonwoo;Murali Mohan Reddy, P. S.;Au, Qingyan;Yoon, Il Sang;Tremblay, Marie-Helene;Yip, Gary;Cher, Charmian;Zhang, Bin;Barber, Jack R.;Ng, Shi Chung. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.SDS of cas: 55219-11-9 This article mentions the following:
Chloro-oxime derivatives were investigated as novel small mol. chaperone amplifiers. Lead optimization led to the discovery of compounds that displayed potent HSF1 activation activity, significant cytoprotection in MG-132 stress, ER stress and PolyQ stress cell models (EC50 < 10 μM). In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9SDS of cas: 55219-11-9).
Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.SDS of cas: 55219-11-9
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem