Iron(II)-Catalyzed Direct Cyanation of Arenes with Aryl(cyano)iodonium Triflates was written by Shu, Zhibin;Ji, Wenzhi;Wang, Xi;Zhou, Yujing;Zhang, Yan;Wang, Jianbo. And the article was included in Angewandte Chemie, International Edition in 2014.Application In Synthesis of Benzo[b]thiophene-2-carbonitrile This article mentions the following:
A direct oxidative cyanation of arenes under iron [Fe(II)] catalysis with [3,5-bis(trifluoromethyl)phenyl](cyano)iodonium triflate (DFCT) as the cyanation agent has been developed. The reaction is applicable to wide range of aromatic substrates, including polycyclic structures and heteroaromatic compounds Under optimized conditions the synthesis of the target compounds was achieved using acetic acid iron(2+) salt (2:1) [iron(II) acetate] as catalyst and cyano[4-(trifluoromethyl)phenyl]iodonium trifluoromethanesulfonate (1:1) as cyano group source. Starting materials included 1,4-dimethylbenzene (alkyl arene), naphthalene, anthracene, phenanthrene, 1-[tris(1-methylethyl)silyl]-1H-pyrrole, 1-[(4-methylphenyl)sulfonyl]-1H-pyrrole, benzo[b]thiophene, benzofuran, 1-(3-methyl-1H-indol-1-yl)-ethanone (indole derivative),. The title compounds thus formed included aromatic nitriles, such as benzonitrile derivatives, 9-anthracenecarbonitrile, 1-naphthalenecarbonitrile, 1-[(4-methylphenyl)sulfonyl]-1H-pyrrole-2-carbonitrile, 9-phenanthrenecarbonitrile, benzo[b]thiophene-2-carbonitrile, etc. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Application In Synthesis of Benzo[b]thiophene-2-carbonitrile).
Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Application In Synthesis of Benzo[b]thiophene-2-carbonitrile
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem