Day: February 9, 2023

Enhanced Performance of Benzothieno[3,2-b]thiophene (BTT)-Based Bottom-Contact Thin-Film Transistors was written by Huang, Peng-Yi;Chen, Liang-Hsiang;Chen, Yu-Yuan;Chang, Wen-Jung;Wang, Juin-Jie;Lii, Kwang-Hwa;Yan, Jing-Yi;Ho, Jia-Chong;Lee, Cheng-Chung;Kim, Choongik;Chen, Ming-Chou. And the article was included in Chemistry – A European Journal in 2013.Related Products of 6287-82-7 This article mentions the following:

Three new benzothieno[3,2-b]thiophene (BTT; 1) derivatives, which were end-functionalized with Ph (BTT-P; 2), benzothiophenyl (BTT-BT; 3), and benzothieno[3,2-b]thiophenyl groups (BBTT; 4; dimer of 1), were synthesized and characterized in organic thin-film transistors (OTFTs). A new and improved synthetic method for BTTs was developed, which enabled the efficient realization of new BTT-based semiconductors. The crystal structure of BBTT was determined by single-crystal x-ray diffraction. Within this family, BBTT, which had the largest conjugation of the BTT derivatives exhibited the highest p-channel characteristic, with a carrier mobility ≤0.22 cm² V^-1 s^-1 and a current on/off ratio of 1 × 10⁷, as well as good ambient stability for bottom-contact/bottom-gate OTFT devices. The device characteristics were correlated with the film morphologies and microstructures of the corresponding compounds In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Related Products of 6287-82-7).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Related Products of 6287-82-7

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Design, synthesis, and biological evaluation of benzo[b]thiophene 1,1-dioxide derivatives as potent STAT3 inhibitors was written by Li, Wen-Zhen;Xi, Hui-Zhi;Wang, Yi-Jie;Ma, Hong-Bo;Cheng, Zhi-Qiang;Yang, Yu;Wu, Meng-Ling;Liu, Ting-Mei;Yang, Wen;Wang, Qin;Liao, Meng-Ya;Xia, Yong;Zhang, Yi-Wen. And the article was included in Chemical Biology & Drug Design in 2021.Formula: C10H7BrO2S This article mentions the following:

As a member of the signal transducer and activator of transcription (STAT) family, STAT3 plays a critical role in several biol. pathways such as cell proliferation, migration, survival, and differentiation. Due to abnormal continuous activation in tumors, inhibition of STAT3 has emerged as an attractive approach for the treatment of various cancer cells. Herein, we report a series of novel STAT3 inhibitors based on benzo[b]thiophene 1,1-dioxide scaffold and evaluated their anticancer potency. Among them, compound I exhibited the best activity against cancer cells. Compound I induced apoptosis and blocked the cell cycle. Meanwhile, I reduced intracellular ROS content and caused the loss of mitochondrial membrane potential. Further research revealed that I significantly blocked STAT3 phosphorylation and STAT3-dependent dual-luciferase reporter gene experiments showed that compound I has a marked inhibition of STAT3-mediated Firefly luciferase activity. Mol. modeling studies revealed compound I occupied the pocket well with the SH2 domain in a favorable conformation. In the experiment, the researchers used many compounds, for example, Methyl 5-bromobenzo[b]thiophene-2-carboxylate (cas: 7312-11-0Formula: C10H7BrO2S).

Methyl 5-bromobenzo[b]thiophene-2-carboxylate (cas: 7312-11-0) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Formula: C10H7BrO2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Convenient Electrophilic Fluorination of Functionalized Aryl and Heteroaryl Magnesium Reagents was written by Yamada, Shigeyuki;Gavryushin, Andrei;Knochel, Paul. And the article was included in Angewandte Chemie, International Edition in 2010.Computed Properties of C9H7BrS This article mentions the following:

A simple, convenient, and highly versatile one-pot method for converting aromatic and heteroaromatic bromides into corresponding fluorides is developed. This procedure allows a direct access to fluorinated pyridines, thiophenes, pyrroles and isoquinolines as well as to sterically congested fluorine-substituted benzenes, which are otherwise difficult to prepare In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9Computed Properties of C9H7BrS).

3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Computed Properties of C9H7BrS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

The considerable photostability improvement of photochromic terarylene by sulfone group was written by Jeong, Yong-Chul;Gao, Chunji;Lee, In Su;Yang, Sung Ik;Ahn, Kwang-Hyun. And the article was included in Tetrahedron Letters in 2009.HPLC of Formula: 10243-15-9 This article mentions the following:

A photochromic terarylene benzothiophene derivative which has a sulfone group on the upper benzothiophene ring is readily synthesized using Suzuki coupling reaction. It exhibits good photochromic properties. Interestingly, the closed form of this benzothiophene dioxide compound shows a good photostability as well as a thermal stability compared with its reduced analog, that provides a method to enhance the photostability of versatile photochromic terarylenes under UV. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9HPLC of Formula: 10243-15-9).

3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.HPLC of Formula: 10243-15-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Bis[1]benzothieno[2,3-d:2′,3′-d’]anthra[1,2-b:5,6-b’]dithiophene: synthesis, characterization, and application to organic field-effect transistors was written by Hyodo, Keita;Hagiwara, Hideki;Toyama, Ryota;Mori, Hiroki;Soga, Shin-ichi;Nishihara, Yasushi. And the article was included in RSC Advances in 2017.Recommanded Product: 6287-82-7 This article mentions the following:

We report the straightforward synthetic method and characterization of bis[1]benzothieno[2,3-d:2′,3′-d’]anthra[1,2-b:5,6-b’]dithiophene (BBTADT) having nine aromatic rings fused without solubilizing groups. The highest mobility of fabricated OFETs utilizing BBTADT exhibited 2.7 × 10^-2 cm² V^-1 s^-1 in polycrystalline films formed by vapor deposition, depending on the annealing temperatures of a substrate. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Recommanded Product: 6287-82-7).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Recommanded Product: 6287-82-7

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Discovery of fluorescent coumarin-benzo[b]thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors was written by Cai, Guiping;Yu, Wenying;Song, Dongmei;Zhang, Wenda;Guo, Jianpeng;Zhu, Jiawen;Ren, Yuhao;Kong, Lingyi. And the article was included in European Journal of Medicinal Chemistry in 2019.Computed Properties of C10H7BrO2S This article mentions the following:

STAT3 has been extensively studied as a potential antitumor target. Though studies on regulating STAT3 mainly focus on the inhibition of STAT3 phosphorylation at Tyr705 residue, the phosphorylation at Ser727 residue of STAT3 protein is also closely associated with the mitochondrial import of STAT3 protein. N, N-diethyl-7-aminocoumarin is a fluorescent mitochondria-targeting probe. In this study, a series of STAT3 inhibitors were developed by connecting N, N-diethyl-7-aminocoumarin fluorophore with benzo [b]thiophene 1, 1-dioxide moiety. All designed compounds displayed potent anti-proliferative activity against cancer cells. The representative compound 7a(I) was mainly accumulated in mitochondria visualized by its fluorescence. STAT3 phosphorylation was inhibited by I at both Tyr705 and Ser727 residues. I inhibited STAT3 phosphorylation whereas had no influence on the phosphorylation levels of STAT1, JAK2, Src and Erk1/2, indicating good selectivity of I. Moreover, I down-regulated the expression of STAT3 target genes Bcl-2 and Cyclin D1, increased ROS production and remarkably reduced the mitochondrial membrane potential to induce mitochondrial apoptotic pathway. Furthermore, I in vivo suppressed breast cancer 4T1 implanted tumor growth. Taken together, these results highlighted that I might be a promising mitochondria-targeting STAT3 inhibitor for cancer therapy. In the experiment, the researchers used many compounds, for example, Methyl 5-bromobenzo[b]thiophene-2-carboxylate (cas: 7312-11-0Computed Properties of C10H7BrO2S).

Methyl 5-bromobenzo[b]thiophene-2-carboxylate (cas: 7312-11-0) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Computed Properties of C10H7BrO2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

The base-catalyzed skeletal rearrangement of a thianaphthofluorene derivative was written by Cherry, W. H.;Davies, William;Ennis, B. C.;Porter, Quentin Noel. And the article was included in Australian Journal of Chemistry in 1967.Synthetic Route of C8H4Br2S This article mentions the following:

The Diels-Alder adduct of 3-vinylbenzo[b]thiophene and 1,4-naphthoquinone has been shown to undergo a novel base-catalyzed rearrangement, in which its partly hydrogenated 12-thianaphtho[2,3-a]fluorene structure is replaced by a 5-thianaphtho[2,3-b]fluorene (I) structure. 20 references. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Synthetic Route of C8H4Br2S).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Synthetic Route of C8H4Br2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

A practical synthesis of 2-carbonylbenzo[b]thiophenes was written by Hsiao, Chi Nung;Bhagavatula, Lakshmi;Pariza, Richard J.. And the article was included in Synthetic Communications in 1990.Computed Properties of C9H5NS This article mentions the following:

The sequential reduction and alkylation of 2-HSC₆H₄CO₂H gave 2-RCH₂SC₆H₄CH₂OH [R = COMe, COPh, COCMe₃, CO₂Et, cyano, CH(OMe)₂]. The oxidation and intramol. aldol condensation of the latter gave the title compounds I (same R). In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Computed Properties of C9H5NS).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Computed Properties of C9H5NS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

The considerable photostability improvement of photochromic terarylene by sulfone group was written by Jeong, Yong-Chul;Gao, Chunji;Lee, In Su;Yang, Sung Ik;Ahn, Kwang-Hyun. And the article was included in Tetrahedron Letters in 2009.Quality Control of 2,3-Dibromobenzo[b]thiophene This article mentions the following:

A photochromic terarylene benzothiophene derivative which has a sulfone group on the upper benzothiophene ring is readily synthesized using Suzuki coupling reaction. It exhibits good photochromic properties. Interestingly, the closed form of this benzothiophene dioxide compound shows a good photostability as well as a thermal stability compared with its reduced analog, that provides a method to enhance the photostability of versatile photochromic terarylenes under UV. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Quality Control of 2,3-Dibromobenzo[b]thiophene).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Quality Control of 2,3-Dibromobenzo[b]thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Efficient self-contained photoacid generator system based on photochromic terarylenes was written by Li, Ruiji;Nakashima, Takuya;Kanazawa, Rui;Galangau, Olivier;Kawai, Tsuyoshi. And the article was included in Chemistry – A European Journal in 2016.Name: 2,3-Dibromobenzo[b]thiophene This article mentions the following:

A series of highly sensitive neutral photoacid generators (PAGs) based on photochromic terarylenes was prepared Like the example presented herein, these compounds show a subsequent thermal elimination of a Bronsted acid after a light-triggered 6π-electrocyclization, concomitant with the hexatriene aromatization. A novel type of mol. systems was developed, in which one thiazolyl moiety was replaced by a thienyl group. Depending on the solvents and on the nature of the acid source, the quantum yield (QY) for acid generation could reach up to 0.6. Comparative studies on the acid source clearly showed that aromatic leaving groups tend to extinguish the mol. system photoefficiency. A second type was also prepared, in which the nature of the hetero-aromatic rings were identical to our previous example, but their sequence was modified. Therefore, a second level of improvement was achieved in nonpolar solvents, pushing the QY value up to 0.7. Finally, we demonstrated the mesylic acid-releasing PAG as a photocatalyst in a chem. amplified pos. resist system. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Name: 2,3-Dibromobenzo[b]thiophene).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Name: 2,3-Dibromobenzo[b]thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem