Day: February 9, 2023

Chloro-oxime derivatives as novel small molecule chaperone amplifiers was written by Zhou, Yuefen;Vu, Khang;Chen, Yongsheng;Pham, John;Brady, Thomas;Liu, Gang;Chen, Jinhua;Nam, Joonwoo;Murali Mohan Reddy, P. S.;Au, Qingyan;Yoon, Il Sang;Tremblay, Marie-Helene;Yip, Gary;Cher, Charmian;Zhang, Bin;Barber, Jack R.;Ng, Shi Chung. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.SDS of cas: 55219-11-9 This article mentions the following:

Chloro-oxime derivatives were investigated as novel small mol. chaperone amplifiers. Lead optimization led to the discovery of compounds that displayed potent HSF1 activation activity, significant cytoprotection in MG-132 stress, ER stress and PolyQ stress cell models (EC₅₀ < 10 μM). In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9SDS of cas: 55219-11-9).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.SDS of cas: 55219-11-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

A novel synthesis of benzo[b]thiophene was written by Liao, Zutai;Lv, Xuehao;Tao, Ming. And the article was included in Research on Chemical Intermediates in 2013.Reference of 55219-11-9 This article mentions the following:

A convenient method of preparation of benzo[b]thiophene by the using 2-chlorobenzaldehyde and 2-mercaptoacetonitrile as starting materials was reported. The process comprises two steps, neither of which was reported previously. The reactions in this work are clean and efficient. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Reference of 55219-11-9).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Reference of 55219-11-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

One-pot synthesis and property study on thieno[3,2-b]furan compounds was written by Ma, Weimin;Huang, Jiawei;Li, Chao;Jiang, Yueren;Li, Baolin;Qi, Ting;Zhu, Xiaozhang. And the article was included in RSC Advances in 2019.Reference of 6287-82-7 This article mentions the following:

Based on the regioselective intermol. Suzuki coupling and subsequent intramol. Ullmann C-O coupling reactions, one-pot synthesis of benzo[4,5]thieno[3,2-b]benzofurans I (R¹ = H, 3-Cl, 2-n-octyl; R² = H, 8-F, 8-Me, 7-t-Bu) was developed after optimization of the reaction conditions including catalysts, solvents, bases, ligands and reaction times. The one-pot reaction, with only 2 mol% Pd(PPh₃)₄ and 2 mol% copper(I) thiophene-2-carboxylate as the catalysts, K₃PO₄·3H₂O as the base and tert-butanol as the solvent, afforded moderate to good yields (up to 70%) for a variety of substrates. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Reference of 6287-82-7).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Reference of 6287-82-7

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Direct release of nitriles from solid phase was written by Hone, N. D.;Payne, L. J.;Tice, C. M.. And the article was included in Tetrahedron Letters in 2001.Product Details of 55219-11-9 This article mentions the following:

Cleavage conditions are described which allow resin-bound secondary amides to be liberated from Sieber or Rink resin as nitriles. The method was applied to the synthesis of a series of cyano biaryls. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Product Details of 55219-11-9).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Product Details of 55219-11-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis and photochromism studies of 1-(2-methyl-3-benzothiophenyl)-2-[2-methyl-5-(4-azidomethyl)-3-thienyl] perfluorocyclopentene was written by Tang, Yongjun;Xu, Hongyan;Pu, Shouzhi. And the article was included in Applied Mechanics and Materials in 2014.Related Products of 10243-15-9 This article mentions the following:

An unsym. photochromic diarylethene 1-(2-methyl-3-benzothiophenyl)-2-[2-methyl-5-(4-azidomethyl)-3-thienyl] perfluorocyclopentene was synthesized, and its optoelectronic properties were also investigated. The results showed that this compound exhibited reversible photochromism, changing from colorless to dark orange after irradiation with UV light in solution The open-ring isomer of the diarylethene 1o exhibited relatively strong fluorescence at 457 nm in acetonitrile solution (2 × 10-5 mol L-1) when excited at 287 nm. The fluorescence intensity decreased along with the photochromism upon irradiation with 297 nm light. The electrochem. properties indicated that the oxidation onset and the Eg of the open-ring isomer were lower than the closed-ring isomer. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9Related Products of 10243-15-9).

3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Related Products of 10243-15-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Reversible Photoswitching between Fluorescence and Room Temperature Phosphorescence by Manipulating Excited State Dynamics in Molecular Aggregates was written by Wang, Xuanhang;Pan, Guocui;Ren, Haoxuan;Li, Jiashu;Xu, Bin;Tian, Wenjing. And the article was included in Angewandte Chemie, International Edition in 2022.Synthetic Route of C8H4Br2S This article mentions the following:

Regulation of fluorescence-phosphorescence pathways in organic mol. aggregate remains a challenge due to the complicated singlet-triplet excited state dynamics process. Herein, we demonstrated a successful example (o-BFT) to realize photoreversible fluorescence and room temperature phosphorescence (RTP) switching based on an effective strategy of integrating a phosphor (dibenzofuran) with a photoswitch (dithienylbenzothiophene). o-BFT exhibited dual emission of fluorescence and RTP in both powder and doping polymer film. Notably, the long-lived RTP of o-BFT could be repeatedly erased and restored through reversible photocyclization and decyclization under alternate UV and visible photoirradiation In-depth theor. and spectroscopic investigations revealed that the triplet inactivation was dominated by a photo-controlled triplet-to-singlet Forster resonance energy transfer from light-activated o-BFT to photoisomer c-BFT. Yet, the initial fluorescence could be preserved in this process to afford a photoreversible fluorescence-RTP switching. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Synthetic Route of C8H4Br2S).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Synthetic Route of C8H4Br2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Benzo[b]naphtho[1,2-d]thiophene Sulfoxides: Biomimetic Synthesis, Photophysical Properties, and Applications was written by Shen, Xian-Yan;Li, Man;Zhou, Tai-Ping;Huang, Ji-Rong. And the article was included in Angewandte Chemie, International Edition in 2022.Name: 6-Methoxybenzo[b]thiophene This article mentions the following:

A practical synthesis of nonsym. thiophene-fused aromatic systems has been developed that was inspired by the biodegradation of benzothiophene. For the first time, the photophys. properties of a series of π-conjugated benzo[b]naphtho[1,2-d]thiophene (BNT) sulfoxides, I [R = H, Br, MeO, 4-FC₆H₄, R¹ = H, Br, Me, MeO, R² = Br, Cl, CN, etc., R³ = H, Br, MeO, Ph, 3-O₂NC₆H₄, 4-MeOC₆H₄, 4-FC₆H₄, R⁴ = H, Br, MeO, Ph, 3-O₂NC₆H₄, 4-MeOC₆H₄, 4-FC₆H₄, R⁵ = Br, Cl, 2-methoxy-3-pyridinyl, etc., R⁶ = H, Br, Me, R⁷ = H, Br, MeO, 4-FC₆H₄], were explored both in solution and in the solid state. The excellent fluorescence characteristics enable various applications of these compounds In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4Name: 6-Methoxybenzo[b]thiophene).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Name: 6-Methoxybenzo[b]thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

The preparation of some heteroaromatic and aromatic aldehydes was written by Katritzky, Alan R.;He, Hai-Ying;Long, Qiuhe;Cui, Xilin;Level, Julian;Wilcox, Allan L.. And the article was included in ARKIVOC [online computer file] in 2000.Recommanded Product: 3-Bromo-2-methylbenzo[b]thiophene This article mentions the following:

Heteroaromatic α- and β-carboxaldehydes were prepared by the formylation with DMF of α-lithio benzofuran, benzothiophene, N-methylbenzimidazole and 10-methylphenothiazine obtained by direct lithiation and β-lithio compounds from lithium-bromine exchange. Dialkoxybenzaldehydes were prepared by the formylation of dialkoxybenzenes with hexamethylenetetramine (HMTA) or by the alkylation of dihydroxybenzaldehydes with alkyl bromides or iodides. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9Recommanded Product: 3-Bromo-2-methylbenzo[b]thiophene).

3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Recommanded Product: 3-Bromo-2-methylbenzo[b]thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

N-(4-(4-(2,3-Dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with Functionalized Linking Chains as High Affinity and Enantioselective D3 Receptor Antagonists was written by Newman, Amy Hauck;Grundt, Peter;Cyriac, George;Deschamps, Jeffrey R.;Taylor, Michelle;Kumar, Rakesh;Ho, David;Luedtke, Robert R.. And the article was included in Journal of Medicinal Chemistry in 2009.Application of 70060-13-8 This article mentions the following:

In the present report, the D3 receptor pharmacophore is modified in the 2,3-diCl- and 2-OCH₃-phenylpiperazine class of compounds with the goal to improve D3 receptor affinity and selectivity. This extension of structure-activity relationships (SAR) has resulted in the identification of the first enantioselective D3 antagonists (R- and S-22) to be reported, wherein enantioselectivity is more pronounced at D3 than at D2, and that a binding region on the second extracellular loop (E2) may play a role in both enantioselectivity and D3 receptor selectivity. Moreover, we have discovered some of the most D3-selective compounds reported to date that show high affinity (K_i = 1 nM) for D3 and ∼400-fold selectivity over the D2 receptor subtype. Several of these analogs showed exquisite selectivity for D3 receptors over >60 other receptors, further underscoring their value as in vivo research tools. These lead compounds also have appropriate phys. characteristics for in vivo exploration and therefore will be useful in determining how intrinsic activity at D3 receptors tested in vitro is related to behaviors in animal models of addiction and other neuropsychiatric disorders. In the experiment, the researchers used many compounds, for example, 5-Fluoro-1-benzothiophene-2-carboxylic acid (cas: 70060-13-8Application of 70060-13-8).

5-Fluoro-1-benzothiophene-2-carboxylic acid (cas: 70060-13-8) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Application of 70060-13-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Research on photochromic materials with synthesis and application of 1-(2-methyl-3-benzothienyl)-2-[2-methyl-(5-ethynyl)trimethylsilane-3-thienyl]perfluorocyclopentene was written by Ma, Lele;Xu, Hongyan;Liu, Gang. And the article was included in Advanced Materials Research (Durnten-Zurich, Switzerland) in 2014.Name: 3-Bromo-2-methylbenzo[b]thiophene This article mentions the following:

A new unsym. photochromic diarylethene compound, (3-benzothienyl)((5-ethynyl)trimethylsilane-3-thienyl)perfluorocyclopentene I was synthesized, and its optoelectronic properties, such as photochromism and the fluorescence spectra of diarylethene I in hexane solution was investigated. The results showed that this compound exhibited reversible photochromism in solution to yield a cyclopentabenzothienobenzothiophene closed-ring isomer II with a UV/visible absorption at 538 nm. Its fluorescence intensity decreased along with the photochromism from open-ring isomers to closed-ring isomers upon irradiation with 297 nm UV light. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9Name: 3-Bromo-2-methylbenzo[b]thiophene).

3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Name: 3-Bromo-2-methylbenzo[b]thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem