Nickel-catalyzed hydrogenolysis of unactivated carbon-cyano bonds was written by Patra, Tuhin;Agasti, Soumitra;Modak, Atanu;Maiti, Debabrata. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2013.Name: Benzo[b]thiophene-2-carbonitrile This article mentions the following:
Selective hydrogenolysis of C-CN bonds can allow chemists to take advantage of ortho-directing ability, α-C-H acidity, and electron withdrawing ability of the cyano group for synthetic manipulations. We have discovered hydrogenolysis of aryl and aliphatic cyanides under just 1 bar of hydrogen by using a nickel catalyst. E.g., in presence of Ni(COD)2, tricyclohexylphosphine, and AlMe3, hydrogenolysis of aromatic nitrile (I) gave 79% II. This protocol was applied in the aryl cyanide directed functionalization reaction and α-substitution of benzyl cyanides. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Name: Benzo[b]thiophene-2-carbonitrile).
Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Name: Benzo[b]thiophene-2-carbonitrile
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem