Day: February 6, 2023

Optical Properties of Dibenzo[d,d’]thieno[3,2-b;4,5-b’]dithiophene Monocrystals: The Effect of Intermolecular Interactions was written by Alessandrini, Laura;Braga, Daniele;Jaafari, Abdelhafid;Miozzo, Luciano;Mora, Stefano;Silvestri, Leonardo;Tavazzi, Silvia;Yassar, Abderrahim. And the article was included in Journal of Physical Chemistry A in 2011.Formula: C8H4Br2S This article mentions the following:

The polarized UV-visible absorption spectra of dibenzo[d,d’]thieno[3,2-b;4,5-b’]dithiophene single crystals are reported and interpreted to definitively attribute the observed bands and their polarizations. The results provide information on the intermol. interactions and on the aggregation in the condensed phase, which can be of either herringbone- or H-type, depending on the electronic transition taken into considerations, with consequences on the order and polarization of the absorption bands. A relatively easy method is discussed to obtain information on the structural/morphol. properties of different types of samples, including thin films, which were recently proposed for high-performance organic film-effect transistors for their high ionization potential and photostability. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Formula: C8H4Br2S).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Formula: C8H4Br2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Palladium-Catalyzed Carbonylative Synthesis of Phthalimides from 1,2-Dibromoarenes with Molybdenum Hexacarbonyl as Carbon Monoxide Source was written by Wu, Xiao-Feng;Oschatz, Stefan;Sharif, Muhammad;Flader, Anika;Krey, Lisa;Beller, Matthias;Langer, Peter. And the article was included in Advanced Synthesis & Catalysis in 2013.Category: benzothiophene This article mentions the following:

We describe here a convenient and mild, carbon monoxide gas-free palladium-catalyzed procedure to obtain N-substituted phthalimides with molybdenum hexacarbonyl as carbon monoxide precursor. E.g., in presence of molybdenum hexacarbonyl, Pd(OAc)₂, CataCXium A, and DBU in toluene at 100 °C, reaction of 1,2-Br₂C₆H₄ and BuNH₂ gave 84% phthalimide derivative I. These conditions tolerate a number of functional groups on the benzene ring as well as a number of amines and give the corresponding phthalimides in good to excellent yields. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Category: benzothiophene).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Category: benzothiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Benzo[b]thiophenium sulfur-carbon ylides: preparation, structure and comparison with thiophenium analog was written by Vuorinen, Eino;Chalmers, Anthony A.;Dillen, Jan L. M.;Modro, Tomasz A.. And the article was included in Tetrahedron in 1991.Reference of 6287-82-7 This article mentions the following:

A series of new sulfur-carbon ylides I (R¹ = Br, Cl, Me, H, R² = Br, Cl, H, X = OEt, OCMe₃, OMe, Y = Me, OEt, OMe, XY = CH₂CMe₂CH₂) derived from benzo[b]thiophenes II and YCOCN₂COX were prepared and characterized. NMR (¹H, ¹³C) studies revealed that ylides substituted addnl. at position 2 of the thiophene ring can exist as pairs of diastereomers, not interchangeable at room temperature The slow exchange between the two sites was attributed to the restricted rotation about the ylide S-C bond. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Reference of 6287-82-7).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Reference of 6287-82-7

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Thiocyanate radical mediated dehydration of aldoximes with visible light and air was written by Ban, Yong-Liang;Dai, Jian-Ling;Jin, Xiao-Ling;Zhang, Qing-Bao;Liu, Qiang. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Name: Benzo[b]thiophene-2-carbonitrile This article mentions the following:

Herein, a new means of activating aldoximes by an in situ generated thiocyanate radical from ammonium thiocyanate and mol. oxygen at room temp has been discussed. With a catalytic amount of organic dye aizenuranine as the photocatalyst, the dehydration of aldoximes proceeds smoothly under visible light irradiation, providing a simple to handle, excellent functional group tolerance, and metal-free protocol for a wide range of nitriles. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Name: Benzo[b]thiophene-2-carbonitrile).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Name: Benzo[b]thiophene-2-carbonitrile

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis of novel benzo[b]furans and benzo[b]thiophenes: analogs of combretastatin and resveratrol was written by Chauhan, Jay;Monteil, Alexandre R.;Patterson, Steven E.. And the article was included in Heterocyclic Communications in 2010.HPLC of Formula: 6287-82-7 This article mentions the following:

A rapid and efficient synthesis of fused polyphenolic/polymethoxy benzofurans and benzothiophenes that have potential as antitumor agents and components of anti-HIV combination therapy was achieved. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7HPLC of Formula: 6287-82-7).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.HPLC of Formula: 6287-82-7

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Reversible Photomodulation of Electronic Communication in a π-Conjugated Photoswitch-Fluorophore Molecular Dyad was written by Moreno, Javier;Schweighoefer, Felix;Wachtveitl, Josef;Hecht, Stefan. And the article was included in Chemistry – A European Journal in 2016.Quality Control of 3-Bromo-2-methylbenzo[b]thiophene This article mentions the following:

The extent of electronic coupling between a boron dipyrromethene (BODIPY) fluorophore and a diarylethene (DAE) photoswitch has been modulated in a covalently linked mol. dyad by irradiation with either UV or visible light. In the open isomer, both moieties can be regarded as individual chromophores, while in the closed form the lowest electronic (S₀→S₁) transition of the dyad is slightly shifted, enabling photomodulation of its fluorescence. Transient spectroscopy confirms that the dyad behaves dramatically different in the two switching states: while in the open isomer it resembles an undisturbed BODIPY fluorophore, in the closed isomer no fluorescence occurs and instead a red-shifted DAE behavior prevails. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9Quality Control of 3-Bromo-2-methylbenzo[b]thiophene).

3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Quality Control of 3-Bromo-2-methylbenzo[b]thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Design, synthesis, and biological activity evaluation of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives as broad-spectrum antifungal agents was written by Zhao, Liyu;Sun, Yin;Yin, Wenbo;Tian, Linfeng;Sun, Nannan;Zheng, Yang;Zhang, Chu;Zhao, Shizhen;Su, Xin;Zhao, Dongmei;Cheng, Maosheng. And the article was included in European Journal of Medicinal Chemistry in 2022.Synthetic Route of C9H5FO2S This article mentions the following:

To discover antifungal compounds with broad-spectrum and stable metabolism, a series of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives were designed and synthesized. Compounds I [R¹ = 6-F, 6-Cl, 6-Br; R² = 4-F] and [R¹ = 6-Cl, 6-Br; R² = 4-Cl] exhibited excellent broad-spectrum antifungal activity against Candida albicans with MIC values in the range of 0.03-0.5μg/mL, and against Cryptococcus neoformans and Aspergillus fumigatus with MIC values in the range of 0.25-2μg/mL. In addition, compounds I [R¹ = 6-Cl; R² = 4-F] and [R¹ = 6-Cl; R² = 4-Cl] showed high metabolic stability in human liver microsomes in vitro, with the half-life of 80.5 min and 69.4 min, resp. Moreover, compounds I [R¹ = 6-Cl; R² = 4-F] and [R¹ = 6-Cl; R² = 4-Cl] showed weak or almost no inhibitory effect on the CYP3A4 and CYP2D6. The pharmacokinetic evaluation in SD rats showed that compoundI [R¹ = 6-Cl; R² = 4-F] had suitable pharmacokinetic properties and was worthy of further study. In the experiment, the researchers used many compounds, for example, 5-Fluoro-1-benzothiophene-2-carboxylic acid (cas: 70060-13-8Synthetic Route of C9H5FO2S).

5-Fluoro-1-benzothiophene-2-carboxylic acid (cas: 70060-13-8) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is also used in the manufacturing of dyes such as thioindigo.Synthetic Route of C9H5FO2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis and reactions of 2,3,5,6-tetrahydro-2,5-ethano-3-benzazocin-4(1H)-one and a thieno-extended analog: x-ray structure of 3-methyl-2,3,5,6-tetrahydro-2,5-ethano[1]benzothieno[3,2-d]azocin-4(1H)-one was written by Iddon, Brian;Redhouse, Alan D.;Yat, Patrick N.. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1990.Recommanded Product: 10243-15-9 This article mentions the following:

Hexahydromethanobenzocyclooctenone I (X = O) was prepared by condensation of o-xylene-α,α’-diyl dibromide with N-cyclopentylidenepyrrolidine and converted by Beckmann rearrangement of I (X = NOH) into tetrahydroethanobenzazocinone II (R = H). 2,3-Bis(bromomethyl)benzo[b]thiophene was converted similarly into a mixture of tetrahydroethanobenzothienoazocinones III (X¹ = NH, X² = CO; X¹ = CO, X² = NH). II (R = H) was N-methylated and II (R = H, Me) were reduced with LiAlH₄ to the saturated products. Conversion of II (R = H) into the corresponding thiolactam with P₂S₅ followed by alkylation gave an N– or S-alkylated derivative, (e.g., IV, R = Me, Et), depending on the reagent and reaction conditions. The structures of a number of compounds in this work are based on the x-ray anal. of III (X¹ = CO, X² = NMe). In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9Recommanded Product: 10243-15-9).

3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Recommanded Product: 10243-15-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis, photochromism and holographic optical recording of a photochromic diarylethene with a chlorine atom was written by Wang, Liqin;Pu, Shouzhi;Liu, Weijun. And the article was included in Advanced Materials Research (Durnten-Zurich, Switzerland) in 2011.Name: 3-Bromo-2-methylbenzo[b]thiophene This article mentions the following:

A new unsym. photochromic diarylethene 1-(2-methyl-benzothiophenyl)-2-(2-methyl-5-(2-chlorophenyl))perfluoroncyclopentene (1a), was synthesized and its optoelectronic properties, such as photochromism in solution as well as in PMMA amorphous films, fluorescences and the fluorescence spectra of diarylethene 1a depended on the concentration were investigated. Using diarylethene 1/PMMA film as recording medium and a linearly polarized 633 nm laser diode for recording and readout, polarization multiplexed image recording can be carried out in this film, which illustrated that the diarylethene can be potentially used as holog. optical recording medium. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9Name: 3-Bromo-2-methylbenzo[b]thiophene).

3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Name: 3-Bromo-2-methylbenzo[b]thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Nonsymmetrical 3,4-Dithienylmaleimides by Cross-Coupling Reactions with Indium Organometallics: Synthesis and Photochemical Studies was written by Mosquera, Angeles;Fernandez, M. Isabel;Canle Lopez, Moises;Perez Sestelo, Jose;Sarandeses, Luis A.. And the article was included in Chemistry – A European Journal in 2014.Computed Properties of C9H7BrS This article mentions the following:

The synthesis and photochem. study of novel nonsym. 1,2-dithienylethenes (DTEs) with a maleimide bridge have been carried out. The synthetic approach to the DTEs was based on successive selective palladium-catalyzed cross-coupling reactions of 5-substituted-2-methyl-3-thiophenyl indium reagents with 3,4-dichloromaleimides. The required organoindium reagents were prepared from 2-methyl-3,5-dibromothiophene by a selective (C-5) coupling reaction with triorganoindium compounds (R₃In) and subsequent metal-halogen exchange. The coupling reactions usually gave good yields and have a high atom economy with substoichiometric amounts of R₃In. The results of photochem. studies show that these novel dithienylmaleimides undergo a photocyclization reaction upon irradiation in the UV region and a photocycloreversion after excitation in the visible region, thus they can be used as photochem. switches. ON-OFF operations can be repeated in successive cycles without appreciable loss of effectiveness in the process. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9Computed Properties of C9H7BrS).

3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Computed Properties of C9H7BrS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem