Potential hypolipidemic agents. XX. Synthesis and lipid-lowering properties of annelated thiophenecarboxylic acids was written by Gronowitz, Salo;Herslof, Margareta;Svenson, Rolf;Bondesson, Goran;Magnusson, Olle;Stjernstrom, Nils E.. And the article was included in Acta Pharmaceutica Suecica in 1978.Quality Control of 5-Fluoro-1-benzothiophene-2-carboxylic acid This article mentions the following:
Condensed thiophenecarboxylic acids I–V (R = H, Cl, F; R1 = H, Cl; R2 = H, Cl, F, Me, R3 = H; R2 = H, R3 = Cl) were prepared The V had anticholesteremic and hypolipemic activity superior that of clofibrate, whereas IV was inactive. Chlorination increased the hypolipemic activity of I through III. In the experiment, the researchers used many compounds, for example, 5-Fluoro-1-benzothiophene-2-carboxylic acid (cas: 70060-13-8Quality Control of 5-Fluoro-1-benzothiophene-2-carboxylic acid).
5-Fluoro-1-benzothiophene-2-carboxylic acid (cas: 70060-13-8) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Quality Control of 5-Fluoro-1-benzothiophene-2-carboxylic acid
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem