Cu-Catalyzed Cyanation of Arylboronic Acids with Acetonitrile: A Dual Role of TEMPO was written by Zhu, Yamin;Li, Linyi;Shen, Zengming. And the article was included in Chemistry – A European Journal in 2015.Recommanded Product: 55219-11-9 This article mentions the following:
The cyanation of arylboronic acids using acetonitrile as the “CN” source was achieved under a Cu(cat.)/TEMPO system (TEMPO = 2,2,6,6-tetramethylpiperidine N-oxide). The broad substrate scope includes a variety of electron-rich and electron-poor arylboronic acids, which react well to give the cyanated products in high to excellent yields. Mechanistic studies revealed that TEMPO-CH2CN, generated in situ, is an active cyanating reagent and shows high reactivity for the formation of the CN– moiety. Moreover, TEMPO acts as a cheap oxidant to enable the reaction to be catalytic in copper. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Recommanded Product: 55219-11-9).
Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Recommanded Product: 55219-11-9
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem