Synthesis and evaluation of benzo[b]thiophene derivatives as inhibitors of alkaline phosphatases was written by Li, Lina;Chang, Lei;Pellet-Rostaing, Stephane;Liger, Francois;Lemaire, Marc;Buchet, Rene;Wu, Yuqing. And the article was included in Bioorganic & Medicinal Chemistry in 2009.Recommanded Product: Benzo[b]thiophene-2-carbonitrile This article mentions the following:
Presence of basic calcium phosphate in knee joints of osteoarthritis patients could be prevented by inhibiting tissue non-specific alk. phosphatase (TNAP) activity. Levamisole or the L stereoisomer of tetramisole (a known TNAP inhibitor) has been used as a treatment for curing rheumatoid arthritis but its therapeutical use is limited due to side effects. We report the synthesis and the TNAP inhibition property of benzo[b]thiophene derivatives, among which benzothiopheno-tetramisole and benzothiopheno-2,3-dehydrotetramisole, which could be involved in a drug therapy for osteoarthritis. Two water soluble racemic benzothiopheno-tetramisole and -2,3-dehydrotetramisole with apparent inhibition constants K i = 85 ± 6 μM and 135 ± 3 μM (n = 3) comparable to that of enantiomeric levamisole 93 ± 4 μM were found. Several novel derivatives showed more pronounced inhibition properties towards intestinal alk. phosphatase than TNAP. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Recommanded Product: Benzo[b]thiophene-2-carbonitrile).
Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Recommanded Product: Benzo[b]thiophene-2-carbonitrile
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem