Synthesis of novel 2-aminoimidazo[4,5-b]pyridines, including the thieno analogue of the cooked-food mutagen IFP was written by Bjoerk, Malin;Grivas, Spiros. And the article was included in Journal of Heterocyclic Chemistry in 2006.Formula: C8H4Br2S This article mentions the following:
Eight new compounds, including three new ring systems obtained via the Friedlaender condensation of ortho-aminothiophenecarbaldehydes with creatinine, are reported. The condensation afforded I, which is the thieno analog of the cooked-food mutagen IFP (2-amino-1,6-dimethylfuro[2,3-e]imidazo[4,5-b]pyridine), and the benzothieno[2,3-e]- and benzothieno[3,2-e]imidazo[4,5-b]pyridines. Attempts to condense II with isocreatinine were unsuccessful. Desulfurization of III gave the known cooked-food carcinogen PhIP. The 2-nitro and 2-hydroxy derivatives of III are reported. The related 2-amino-1-methyl-imidazo[4,5-b]benzothiophene was synthesized by a different route. Fully assigned 1H and 13C NMR data of all new compounds are reported. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Formula: C8H4Br2S).
2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Formula: C8H4Br2S
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem