Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 4. SAR studies on the conformationally restricted C3-side chain of hydroxybenzo[B]thiophenes was written by Takeuchi, Kumiko;Kohn, Todd J.;Sall, Daniel J.;Denney, Michael L.;McCowan, Jefferson R.;Smith, Gerry F.;Gifford-Moore, Donetta S.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 1999.Formula: C9H8OS This article mentions the following:
A novel series of benzo[b]thiophene diamine thrombin inhibitors with a conformationally restricted C3-side chain was investigated. The constrained C3-side chain by a cyclohexyl ring contributed to not only an additive but also a synergistic effect on the thrombin inhibitory activity. The SAR studies resulted in the discovery of a potent thrombin inhibitor (I) that was over 750-fold more potent than the initial lead compound In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4Formula: C9H8OS).
6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Formula: C9H8OS
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem