New scaffolds for the design of selective estrogen receptor modulators was written by Martin-Santamaria, Sonsoles;Rodriguez, Jose-Juan;de Pascual-Teresa, Sonia;Gordon, Sandra;Bengtsson, Martin;Garrido-Laguna, Ignacio;Rubio-Viqueira, Belen;Lopez-Casas, Pedro P.;Hidalgo, Manuel;de Pascual-Teresa, Beatriz;Ramos, Ana. And the article was included in Organic & Biomolecular Chemistry in 2008.Safety of 6-Methoxybenzo[b]thiophene This article mentions the following:
In the present work we report the synthesis of four new ER ligands which can be used as scaffolds for the introduction of the basic side chains necessary for antiestrogenic activity. Affinities and agonist/antagonist characterization of the ligands for both ERα and ERβ have been determined in a competitive radioligand assay, and in an in vitro coactivator recruitment functional assay, resp. Mol. modeling techniques have been used in order to rationalize the exptl. results. Compound 2 is reported as a novel ERβ-agonist/ERα-antagonist. Two compounds show an interesting antitumor profile towards two pancreatic cancer cell lines and have been selected for in vivo assays. In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4Safety of 6-Methoxybenzo[b]thiophene).
6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Safety of 6-Methoxybenzo[b]thiophene
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem