Palladium-Catalyzed Direct Decarbonylative Cyanation of Aryl Carboxylic Acids was written by Zhang, Guofu;Miao, Huihui;Guan, Chenfei;Ding, Chengrong. And the article was included in Journal of Organic Chemistry in 2022.COA of Formula: C9H5NS This article mentions the following:
The direct transformation of aryl carboxylic acids to aryl nitrile compounds is an interesting topic because carboxylic acids are not only abundant in nature but are also inexpensive and stable. Here, the synthesis of a series of aryl nitriles by palladium-catalyzed decarbonylative cyanation of carboxylic acids without base has been achieved. The successful decarbonylative cyanation of drug mols. and gram-scale reaction to verify the practicality and operability of this method are analyzed. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9COA of Formula: C9H5NS).
Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.COA of Formula: C9H5NS
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem