Robust Palladium-Catalyzed Arylation of Catalyst-Poisoning ortho-Sulfanyl Aryl Halides with Tetraarylborates and Its Application to Synthesis of π-Extended Dibenzothiophenes was written by Vasu, Dhananjayan;Hausmann, Jan Niklas;Saito, Hayate;Yanagi, Tomoyuki;Yorimitsu, Hideki;Osuka, Atsuhiro. And the article was included in Asian Journal of Organic Chemistry in 2017.Application In Synthesis of 2,3-Dibromobenzo[b]thiophene This article mentions the following:
Bis(tri-tert-butylphosphine)palladium-catalyzed arylation of ortho-sulfanyl aryl halides with sodium tetraarylborates proceeds smoothly without any addnl. bases in high yields, providing a reliable route to 2-sulfanylbiaryls. The conditions are applicable to aryl chloride and iodide as well as bromides. A variety of functional groups were tolerated. This arylation protocol offers a practical solution to overcome the poisoning behavior of aryl sulfides in such cross-coupling arylation. In addition, this strategy provides a short and efficient access to dibenzothiophenes in combination with a Pummerer-type cyclization. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Application In Synthesis of 2,3-Dibromobenzo[b]thiophene).
2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Application In Synthesis of 2,3-Dibromobenzo[b]thiophene
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem