Palladium-catalyzed synthesis of nitriles from N-phthaloyl hydrazones was written by Ano, Yusuke;Higashino, Masaya;Yamada, Yuki;Chatani, Naoto. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Application of 55219-11-9 This article mentions the following:
The Pd-catalyzed transformation of N-phthaloyl hydrazones into nitriles RC≡N [R = 3-pyridyl, 4-MeC6H4, 2-naphthyl, etc.] and R(Me)C=CHC≡N involving the cleavage of an N-N bond was reported. The use of N-heterocyclic carbene as a ligand was essential for the success of the reaction. N-Phthaloyl hydrazones prepared from aromatic aldehydes or cyclobutanones were applicable to this transformation, which gaves aryl nitriles RC≡N or alkenyl nitriles R(Me)C=CHC≡N, resp. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Application of 55219-11-9).
Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Application of 55219-11-9
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem