Efficient synthesis of 3-oxygenated benzothiophene derivatives was written by Zhang, Fuyao;Mitchell, David;Pollock, Patrick;Zhang, Tony Y.. And the article was included in Tetrahedron Letters in 2007.Reference of 90560-10-4 This article mentions the following:
An efficient synthesis of 2-bromo-3-(aryloxy)benzothiophene derivatives by a conjugate addition-elimination sequence of 2,3-dibromobenzothiophene dioxides with phenolic nucleophiles was developed. These benzothiophene derivatives serve as important intermediates for the synthesis of SERM (selective estrogen receptor modulator) analogs. In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4Reference of 90560-10-4).
6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Reference of 90560-10-4
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem