Reactions of bromothianaphthenes with piperidine. Reinvestigation was written by Reinecke, Manfred G.;Mohr, William B.;Adickes, H. Wayne;De Bie, D. A.;Van der Plas, H. C.;Nijdam, K.. And the article was included in Journal of Organic Chemistry in 1973.Safety of 2,3-Dibromobenzo[b]thiophene This article mentions the following:
The reaction of 3-bromothianaphthene with piperidine was reinvestigated and found to give primarily the normal (I) but also some of the cine-substitution product (II), which is also the only product from the reaction of 2-bromothianapthene. The previously reported results can be rationalized by the effects of air metals, and impure starting material on the reaction. 2,3-Dibromothianaphthene (III) also gives II under these conditions probably via the 2-piperidino-3-bromo analog (IV), which was isolated under milder conditions, could be converted to II in high yield, and was synthesized from II via an iminium salt. 2,3-Dipiperidinothianaphthene was isolated in trace amounts from the reactions of III and IV with piperidine. Possible mechanisms for some of these reactions are discussed. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Safety of 2,3-Dibromobenzo[b]thiophene).
2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Safety of 2,3-Dibromobenzo[b]thiophene
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem