Small-Molecule Inhibitors of the TLR3/dsRNA Complex was written by Cheng, Kui;Wang, Xiaohui;Yin, Hang. And the article was included in Journal of the American Chemical Society in 2011.Application of 70060-13-8 This article mentions the following:
The protein-RNA interface has been regarded as “undruggable” despite its importance in many biol. processes. The toll-like receptor 3 (TLR3)/double-stranded RNA (dsRNA) complex provides an exciting target for a number of infectious diseases and cancers. We describe the development of a series of small-mol. probes that were shown to be competitive inhibitors of dsRNA binding to TLR3 with high affinity and specificity. In a multitude of assays, compound 4a was profiled as a potent antagonist to TLR3 signaling and also repressed the expression of downstream signaling pathways mediated by the TLR3/dsRNA complex, including TNF-α and IL-1β. In the experiment, the researchers used many compounds, for example, 5-Fluoro-1-benzothiophene-2-carboxylic acid (cas: 70060-13-8Application of 70060-13-8).
5-Fluoro-1-benzothiophene-2-carboxylic acid (cas: 70060-13-8) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Application of 70060-13-8
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem