Synthesis of functionalized benzothiophenes and dibenzothiophenes by two fold Heck and subsequent 6π-electrocyclization reactions of 2,3-dibromothiophenes and 2,3-dibromobenzothiophenes was written by Tengho Toguem, Serge-Mitherand;Malik, Imran;Hussain, Munawar;Iqbal, Jamshed;Villinger, Alexander;Langer, Peter. And the article was included in Tetrahedron in 2013.Electric Literature of C8H4Br2S This article mentions the following:
Benzothiophenes and dibenzothiophenes were prepared by two-fold Heck reactions of 2,3-dibromothiophene and 2,3-dibromobenzothiophene, resp., followed by thermal 6π-electrocyclization and dehydrogenative aromatization reactions. The Heck reaction of 2,3-dibromothiophene and 2,3-dibromobenzothiophene with 1 equiv of alkenes proceeded with different regioselectivities and afforded 2-alkenylthiophenes and 3-alkenylbenzothiophenes. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Electric Literature of C8H4Br2S).
2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Electric Literature of C8H4Br2S
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem