Regioselective Synthesis of Naphthothiophenes by Pd Catalyzed Cross-Coupling Reactions and Alkyne-Carbonyl Metathesis was written by Sobhani, Maryam;Villinger, Alexander;Ehlers, Peter;Langer, Peter. And the article was included in Journal of Organic Chemistry in 2022.Name: 2,3-Dibromobenzo[b]thiophene This article mentions the following:
Naphthothiophenes I [R1 = H, 8-MeO; R2 = H, 3-Me, 4-MeO, etc.] and II [R3 = H, 2-F, 3-MeO; R4 = H, 3-F, 3-Me, etc.] were prepared from com. available 2,3-dibromothiophenes in two steps by one-pot Suzuki/Sonogashira or Sonogashira/Suzuki coupling reactions, followed by intramol. alkyne-carbonyl-metathesis reactions. The final cyclization reaction proceeds in the presence of p-toluenesulfonic acid and provides a rapid access to two series of isomeric naphthothiophenes I and II. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Name: 2,3-Dibromobenzo[b]thiophene).
2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Name: 2,3-Dibromobenzo[b]thiophene
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem