Robertson, David W. et al. published their research in European Journal of Medicinal Chemistry in 1986 | CAS: 90560-10-4

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Recommanded Product: 6-Methoxybenzo[b]thiophene

Structure-activity relationships of arylimidazopyridine cardiotonics; synthesis and inotropic activity of benzthienyl- and naphthyl-substituted imidazopyridines and purines was written by Robertson, David W.;Krushinski, Joseph H.;Beedle, E. E.;Wyss, V.;Pollock, G. Don;Hayes, J. Scott. And the article was included in European Journal of Medicinal Chemistry in 1986.Recommanded Product: 6-Methoxybenzo[b]thiophene This article mentions the following:

Several ring-annelated analogs I [A, B = N, CH; R, R1 = H, OMe (1- or 2-naphthyl derivatives)] and II (A, B = N, CH; R = H, OMe; X = S, O, or SO; Y = CH2, O; z = 1-2) of the potent inotrope isomazole (LY175326) were prepared and evaluated for their inotropic activities. The dihydrobenzthienyl analog of isomazole II (A = N; B = CH; R = OMe; X = SO; Y = CH2; z = 1) [103811-54-7], was prepared via a 9-step sequence starting from 3-methoxybenzenethiol  [15570-12-4]. All other analogs were synthesized in 2-3 steps from readily available starting materials. In the naphthyl series, only the 2-naphthyl analogs had significant in vitro activity, and the imidazo[4,5-c]pyridine analog [98410-79-8] possessed greater intrinsic potency than either the analogous imidazo[4,5-b]pyridine [89574-50-5] or purine analog [98410-77-6]. I.v. administration of 8 mg/kg of the 2-naphthyl analog I ( A = N; B = CH; R = 3-OMe; R1 = 6-OMe) [98410-71-0] markedly increased contractility (+ 140 %) while having relatively minor effects on heart rate (+ 14 %); mean arterial blood pressure was not changed. The dihydrobenzthienyl analog of isomazole was the most potent compound tested, with an ED50 in anesthetized dogs of 2.0 mg/kg. In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4Recommanded Product: 6-Methoxybenzo[b]thiophene).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Recommanded Product: 6-Methoxybenzo[b]thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem