Application of directed metalation in synthesis. Part 4: Expedient synthesis of substituted benzo[b]thiophene and naphthothiophene was written by Mukherjee, Chandrani;Kamila, Sukanta;De, Asish. And the article was included in Tetrahedron in 2003.Recommanded Product: 90560-10-4 This article mentions the following:
A short, simple and inexpensive synthesis of several diversely substituted benzo[b]thiophenes, e.g. I, and one naphthothiophene II is described. The method involves introduction of methylsulfanyl group ortho- to the amide function of readily available N,N-diethylamides of aryl carboxylic acid by directed metalation. Thioindoxyls, obtained in high yields through side-chain deprotonation and cyclization in one pot, are reduced to benzo[b]thiophene or naphthothiophene. In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4Recommanded Product: 90560-10-4).
6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Recommanded Product: 90560-10-4
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem