Month: December 2022

Rational design of a visible-light photochromic diarylethene: a simple strategy by extending conjugation with electron donating groups was written by Tang, Shanliang;Song, Fengling;Lu, Meiheng;Han, Keli;Peng, Xiaojun. And the article was included in Science China: Chemistry in 2019.Reference of 10243-15-9 This article mentions the following:

Photochromic diarylethenes have been widely used in many fields. However, their cyclization process must be induced by UV light. In this article, a simple strategy is developed by extending π-conjugation with electron donating groups. The modified diarylethene derivative can photocyclize under 405-nm light with a good photochromic efficiency. Meanwhile, its absorption and moderate fluorescence can be switched effectively in both directions by visible lights (405 and 520 nm, resp.) in different solutions and in living cells. We believe that this simple method will become a versatile strategy for developing various diarylethylenes with visible-light photochromism. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9Reference of 10243-15-9).

3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Reference of 10243-15-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Bis[1]benzothieno[1,4]thiazines: planarity, enhanced redox activity and luminescence by thieno-expansion of phenothiazine was written by Schneeweis, Arno P. W.;Hauer, Simone T.;Reiss, Guido J.;Mueller, Thomas J. J.. And the article was included in Chemistry – A European Journal in 2019.Product Details of 6287-82-7 This article mentions the following:

Two-fold Buchwald-Hartwig aminations selectively furnish three regioisomers of bis[1]benzothieno[1,4]thiazines; x-ray structure analyses and DFT calculations were corroborated for correlation of their electronic properties. All regioisomers outscore the parent compound phenothiazine with respect to a low-lying oxidation potential and reversible redox activity. The anti-anti bis[1]benzothieno[3,2-b:2′,3′-e][1,4]thiazines possess the lowest oxidation potentials in this series and displayed pronounced green luminescence in solution (Φ_F≈20%) and in the solid state. Syn-anti regioisomers were only weakly luminescent in solution, but showed aggregation-induced emission enhancement and solid-state luminescence. Most interestingly, x-ray structure analyses revealed that anti-anti derivatives have an amazingly coplanar structure of the pentacyclic anellated 1,4-thiazine system, emphasizing a structural similarity to heteroacenes. The calculated theor. nucleus-independent chem. shifts addnl. suggested that these 8π-electron core systems can be considered as the first electronically unbiased anellated 1,4-thiazines with antiarom. character. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Product Details of 6287-82-7).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Product Details of 6287-82-7

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Transition-Metal-Free Synthesis of Heterobiaryls through 1,2-Migration of Boronate Complex was written by Paul, Swagata;Das, Kanak Kanti;Manna, Samir;Panda, Santanu. And the article was included in Chemistry – A European Journal in 2020.SDS of cas: 90560-10-4 This article mentions the following:

The synthesis of a diverse range of heterobiaryls has been achieved by a transition-metal-free sp²-sp² cross-coupling strategy using lithiated heterocycle, aryl or heteroaryl boronic ester and an electrophilic halogen source. The construction of heterobiaryls was carried out through electrophilic activation of the aryl-heteroaryl boronate complex, which triggered 1,2-migration from boron to the carbon atom. Subsequent oxidation of the intermediate boronic ester afforded heterobiaryls in good yield. A comprehensive ¹¹B NMR study has been conducted to support the mechanism. The cross coupling between two nucleophilic cross coupling partners without transition metals reveals a reliable manifold to procure heterobiaryls in good yields. Various heterocycles like furan, thiophene, benzofuran, benzothiophene, and indole are well tolerated. Finally, the gram scale synthesis of the intermediates for an anticancer drug and OLED material using this methodol. has been successfully demonstrated. In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4SDS of cas: 90560-10-4).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.SDS of cas: 90560-10-4

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Efficient synthesis, photochromic properties and application of a new unsymmetrical diarylethene was written by Wang, Renjie;Xia, Hongying;Pu, Shouzhi;Cui, Shiqiang. And the article was included in Key Engineering Materials in 2011.Recommanded Product: 10243-15-9 This article mentions the following:

A new unsym. photochromic diarylethene compound, [1-(2-methyl-5-(3-fluorophenyl)-3-thienyl) 2-(2-methyl-3-benzothienyl)]perfluorocyclopentene (1o), was synthesized and its photochem. properties, such as photochromism and fluorescence in solution as well as in PMMA amorphous film were investigated in detail. The results showed that the compound exhibited remarkable photochromism, changing from colorless to violet after irradiation with 297 nm UV light both in solution and in PMMA film. Finally, using this dithienylethene as recording medium, polarization optical recording was carried out successfully. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9Recommanded Product: 10243-15-9).

3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Recommanded Product: 10243-15-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Di(benzothienyl)cyclobutenes: Toward Strained Photoswitchable Fluorophores was written by Sysoiev, Dmytro;Prochazkova, Eliska;Semenenko, Aleksander;Pohl, Radek;Shishkina, Svitlana;Klepetarova, Blanka;Shvadchak, Volodymyr;Yushchenko, Dmytro A.. And the article was included in ChemPlusChem in 2020.Product Details of 10243-15-9 This article mentions the following:

Bis(benzothienyl)ethene sulfones are very interesting mols. for super-resolution microscopy due to their photoswitching properties. However, functionalization of the ‘classical’ bis(benzothienyl)ethene sulfones with a five-membered central ring leads to significant decrease of quantum yields of photoconversion of the fluorescent closed form of the dye to the non-fluorescent open form that limits their application in microscopy. Here, we designed and synthesized diarylethenes with a fluorinated four-membered central ring that adds extra strain to the closed form of the dye. The reaction mechanism of their formation was studied, and byproducts formed upon structural rearrangement of the benzothiophene fragment were characterized. The photochromic properties of the new mols. were investigated by NMR and absorption spectroscopy. Some of these compounds show enhanced tendency to ring opening and have quantum yields of the ring-opening reaction in the range of 0.2-0.5. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9Product Details of 10243-15-9).

3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Product Details of 10243-15-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Stability of 3-benzo[b]thienyl-lithium was written by Dickinson, R. P.;Iddon, B.. And the article was included in Tetrahedron Letters in 1970.HPLC of Formula: 10243-15-9 This article mentions the following:

Title compound (I) prepared from 3-bromobenzo[b]thiophene and BuLi was unstable in Et2O above – 70° and at 20° in the presence of Me2SO4 gave o-MeSC6H4CCH, o-MeSC6H4CCMe, benzo[b]thiophene, and 3-bromo-2-methylbenzo[b]thiophene. After 18 hr at 20° o-BuSC6H4CCMe was also obtained. Treatment of I with CO2 after 30 min at 20° gave benzo[b]thiophene-2-carboxylic acid and its 3-bromo derivative In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9HPLC of Formula: 10243-15-9).

3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.HPLC of Formula: 10243-15-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Concise synthesis and biological evaluation of 2-Aryl-3-Anilinobenzo[b]thiophene derivatives as potent apoptosis-inducing agents was written by Romagnoli, Romeo;Preti, Delia;Hamel, Ernest;Bortolozzi, Roberta;Viola, Giampietro;Brancale, Andrea;Ferla, Salvatore;Morciano, Giampaolo;Pinton, Paolo. And the article was included in Bioorganic Chemistry in 2021.Formula: C9H8OS This article mentions the following:

Many clin. used agents active in cancer chemotherapy exert their activity through the induction of cell death (apoptosis) by targeting microtubules, altering protein function or inhibiting DNA synthesis. The benzo[b]thiophene scaffold holds a pivotal place as a pharmacophore for the development of anticancer agents, and, in addition, this scaffold has many pharmacol. activities. In the present study, a new series of 2-aryl-3-(3,4,5-trimethoxyanilino)-6-methoxybenzo[b]thiophenes I (R =H, 4-F, 4-CH₃ etc) are synthesized and the structure-activity relationship was examined by modification of the aryl group at its 2-position with electron-withdrawing (F) or electron-releasing (alkyl and alkoxy) groups. Authors found that small substituents, such as fluorine or Me, could be placed in the para-position of the 2-Ph ring, and these modifications only slightly reduced antiproliferative activity relative to the unsubstituted 2-Ph analog. Compounds I (R = H) and I (R = 4-F) exhibited the greatest antiproliferative activity among the tested compounds The treatment of both Caco2 (not metastatic) and HCT-116 (metastatic) colon carcinoma cells with I (R = H) and I (R = 4-F) triggered a significant induction of apoptosis. The same effect was not observed with non-transformed colon 841 CoN cells. A potential addnl. effect during mitosis for compound I (R = H) in metastatic cells and compound I (R = 4-F) in non-metastatic cells was also observed In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4Formula: C9H8OS).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Formula: C9H8OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis and properties of a novel photochromic compound was written by Wang, Liqin;Pu, Shouzhi;Liu, Weijun. And the article was included in Proceedings of SPIE in 2012.Safety of 3-Bromo-2-methylbenzo[b]thiophene This article mentions the following:

A new unsym. photochromic diarylethene (I) was synthesized and its optoelectronic properties, such as photochromism in solution as well as in poly(Me methacrylate) (PMMA) amorphous films, and the fluorescence spectra were investigated. With a linearly polarized 633 nm laser diode for recording and readout, polarization multiplexed images were recorded in this film, which illustrated that the diarylethene can be potentially used as holog. optical recording medium. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9Safety of 3-Bromo-2-methylbenzo[b]thiophene).

3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Safety of 3-Bromo-2-methylbenzo[b]thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

A novel photochromic diarylethene based on pyrazole and benzothiophene moieties for optical recording was written by Liu, Hongliang;Pu, Shouzhi;Cui, Shiqiang;Liu, Weijun. And the article was included in Advanced Materials Research (Durnten-Zurich, Switzerland) in 2011.Quality Control of 3-Bromo-2-methylbenzo[b]thiophene This article mentions the following:

A novel photochromic diarylethene I containing pyrazole moiety was synthesized and its photochromic and fluorescent properties were also investigated. The compound exhibited remarkable photochromism, changing from colorless to purple after irradiation with UV light both in solution and in PMMA film. In hexane solution and in PMMA film, the open-ring isomer I exhibited relatively remarkable fluorescence. The results indicated that the pyrazole moiety played a very important role during the process of photochromic reaction for the diarylethene derivative Using closed-form of I optical storage was performed successfully. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9Quality Control of 3-Bromo-2-methylbenzo[b]thiophene).

3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Quality Control of 3-Bromo-2-methylbenzo[b]thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Chiral Control in Pentacoordinate Systems: The Case of Organosilicates was written by van der Boon, Leon J. P.;van Gelderen, Laurens;de Groot, Tim R.;Lutz, Martin;Slootweg, J. Chris;Ehlers, Andreas W.;Lammertsma, Koop. And the article was included in Inorganic Chemistry in 2018.Electric Literature of C8H4Br2S This article mentions the following:

Chiral spirosilane I (Δ-9) and silicate II·Li(THF)₄ (Λ-10) were prepared, resolved by preparative chiral HPLC and examined for their absolute configuration with single-crystal x-ray structure determination Chirality at the central element of pentacoordinate systems can be controlled with two identical bidentate ligands. In such cases the topol. Levi-Desargues graph for all the Berry pseudorotations (BPR, maximum 20) reduces to interconnected inner and outer “circles” that represent the dynamic enantiomer pair. High enough barriers of the BPR crossovers between the two circles is all what is needed to ascertain chiral integrity. This is illustrated computationally and exptl. for the 2-phenylbenzothienyl (Ar¹) or 2-phenyl-1-naphthyl (Ar²) organosilicates M[Ar₂SiR] (7a–c, 10a–d, resp., R = Me, Et, Ph, F). The enantiomers of tetraorganosilane precursor Ar²₂Si (9) were resolved by preparative chiral column chromatog. Their chiral integrity persisted on forming the silicates. CD spectra are reported for 10c (Ar = 2-phenyl-1-naphthyl, R = Ph). Fluoro derivative 10d is shown to have its electroneg. F substituent in an equatorial position, is stable toward hydrolysis, and its enantiomers do not racemize at ambient temperatures, while those of 10c racemize slowly. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Electric Literature of C8H4Br2S).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Electric Literature of C8H4Br2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem