High regioselective preparation of mono-bromothiophene derivatives was written by Zhao, Sheng-min;Zhang, Wen-guan. And the article was included in Huaxue Shiji in 2009.Application In Synthesis of 3-Bromo-2-methylbenzo[b]thiophene This article mentions the following:
When thiophene, 2-methylthiophene, 3-methylthiophene, 2,5-dimethylthiophene, benzothiophene and 2-methylbenzothiophene were brominated with N-bromosuccinimide, the products-2-bromothiophene, 2-bromo-5-methylthiophene, 2-bromo-3-methylthiophene, 3-bromo-2, 5-dimethylthiophene, 3-bromobenzothiophene and 3-bromo-2-methylbenzothiophene, resp., were obtained with high regioselectivity at high yield. Only mono-bromothiophene derivatives were produced without formation of dibromothiophene derivatives The brominated products were isolated very conveniently. Me radicals on thiophene derivatives had great influence on the rate of bromination. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9Application In Synthesis of 3-Bromo-2-methylbenzo[b]thiophene).
3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Application In Synthesis of 3-Bromo-2-methylbenzo[b]thiophene
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem