Month: December 2022

Near-ultraviolet absorption spectra of solutions of thianaphthene and some monoderivatives was written by Padhye, M. R.;Desai, S. R.. And the article was included in Transactions of the Faraday Society in 1953.COA of Formula: C9H8OS This article mentions the following:

The spectra of thianaphthene and 5-, 6-, and 7-monomethylthianaphthenes, chlorothianaphthenes, and methoxythianaphthenes in hexane solution were determined in a Beckman DU spectrophotometer, All solutions were 0.00025N in a 1-cm. cell. The effects of Me, Cl, and CH₃O substitution in different positions were systematized and compared with the effects of substitution on the spectrum of naphthalene. In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4COA of Formula: C9H8OS).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.COA of Formula: C9H8OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Fabrication of Robust Spatially Resolved Photochromic Patterns on Cellulose Papers by Covalent Printing for Anticounterfeiting Applications was written by Bretel, Guillaume;Le Grognec, Erwan;Jacquemin, Denis;Hirose, Takashi;Matsuda, Kenji;Felpin, Francois-Xavier. And the article was included in ACS Applied Polymer Materials in 2019.Safety of 3-Bromo-2-methylbenzo[b]thiophene This article mentions the following:

Despite its millennial age, cellulose paper remains the preferred material for domestic and professional printings, covering applications from simple office paperwork to fiducial solutions such as bills, passports, and head letters. The creation of robust photochromic patterns on cellulose papers for anticounterfeiting applications is an important and still partially unaddressed challenge. In this contribution, we report the covalent printing of dibenzothienylethenes as photochromic compounds through a spatially controlled light-mediated thiol-X ligations. Photophys. and theor. studies provide evidence for a reversible photochromism behavior, not affected significantly by the polar environment of the cellulose matrix, and demonstrates a high fatigue resistance over 18 successive write-erase cycles. The strong coloration-discoloration switch can be easily followed by a direct naked-eye readout. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9Safety of 3-Bromo-2-methylbenzo[b]thiophene).

3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Safety of 3-Bromo-2-methylbenzo[b]thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis of polyphenylene derivatives by thermolysis of enediynes and dialkynylaromatic monomers was written by John, Jens A.;Tour, James M.. And the article was included in Tetrahedron in 1997.Application In Synthesis of 2,3-Dibromobenzo[b]thiophene This article mentions the following:

Substituted enediynes and dialkynyl aromatics were prepared using Pd- or Pd/Cu-catalyzed cross coupling procedures, to obtain monomers that were subjected to thermal polymerization to afford the corresponding poly(p-phenylene)s, poly(1,4-naphthalene)s, poly(benzo[c]thiophene)s, and poly(dibenzothiophene)s. The scope of the polymerization process is illustrated based upon substituent patterns and cyclization. moieties. The superb thermal resiliency of the polyphenylenes and Polythiophenylenes obtained was demonstrated using thermogravimetric anal. The polymer structure was generally confirmed using IR data correlations to small mols. that resembled the polymer repeating unit structure. Radical trapping of dimeric intermediates, that were analyzed by GC/MS, further substantiated the proposed mechanistic route. The step-growth polymerization as monitored by GC/MS, further substantiated the proposed mechanistic route. The step-growth polymerization pattern was determined by monitoring the degree of monomer consumption vs. the polymer mol. weight The method is particularly well-suited for polymerization since it requires no exogenous chem. catalysts or reagents for the process, and it is a non-condensation process wherein no volatile byproducts are formed in the polymerization reaction, which makes it amenable to polymer film-forming vapor deposition processes, for, e.g., fabrication of semiconductor devices. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Application In Synthesis of 2,3-Dibromobenzo[b]thiophene).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Application In Synthesis of 2,3-Dibromobenzo[b]thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Vinylindenes and some heteroanalogs in the Diels-Alder reaction. VI. Vinylbenzo[b]thiophenes and ethenetetracarbonitrile was written by Cherry, Winston H.;Craig, John T.;Porter, Quentin N.. And the article was included in Australian Journal of Chemistry in 1979.COA of Formula: C9H7BrS This article mentions the following:

3-Vinylbenzo[b]thiophene and 3 simple homologs give normal Diels-Alder adducts, e.g. I, with ethenetetracarbonitrile, whereas the 3-methyl-2-vinyl- and 2-methyl-3-(1-propenyl) derivatives give cyclobutanes, e.g. II. 2-Methyl-3-vinylbenzo[b]thiophene and ethenetetracarbonitrile give an adduct resulting from reaction of a tautomeric form of the diene, but a naphthalene analog and a phenanthrene analog of this substituted benzothiophene give normal adducts. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9COA of Formula: C9H7BrS).

3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.COA of Formula: C9H7BrS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Benzo[b]naphtho[1,2-d]thiophene Sulfoxides: Biomimetic Synthesis, Photophysical Properties, and Applications was written by Shen, Xian-Yan;Li, Man;Zhou, Tai-Ping;Huang, Ji-Rong. And the article was included in Angewandte Chemie, International Edition in 2022.Safety of 5-Fluoro-1-benzothiophene-2-carboxylic acid This article mentions the following:

A practical synthesis of nonsym. thiophene-fused aromatic systems has been developed that was inspired by the biodegradation of benzothiophene. For the first time, the photophys. properties of a series of π-conjugated benzo[b]naphtho[1,2-d]thiophene (BNT) sulfoxides, I [R = H, Br, MeO, 4-FC₆H₄, R¹ = H, Br, Me, MeO, R² = Br, Cl, CN, etc., R³ = H, Br, MeO, Ph, 3-O₂NC₆H₄, 4-MeOC₆H₄, 4-FC₆H₄, R⁴ = H, Br, MeO, Ph, 3-O₂NC₆H₄, 4-MeOC₆H₄, 4-FC₆H₄, R⁵ = Br, Cl, 2-methoxy-3-pyridinyl, etc., R⁶ = H, Br, Me, R⁷ = H, Br, MeO, 4-FC₆H₄], were explored both in solution and in the solid state. The excellent fluorescence characteristics enable various applications of these compounds In the experiment, the researchers used many compounds, for example, 5-Fluoro-1-benzothiophene-2-carboxylic acid (cas: 70060-13-8Safety of 5-Fluoro-1-benzothiophene-2-carboxylic acid).

5-Fluoro-1-benzothiophene-2-carboxylic acid (cas: 70060-13-8) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Safety of 5-Fluoro-1-benzothiophene-2-carboxylic acid

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

High regioselective preparation of mono-bromothiophene derivatives was written by Zhao, Sheng-min;Zhang, Wen-guan. And the article was included in Huaxue Shiji in 2009.Application In Synthesis of 3-Bromo-2-methylbenzo[b]thiophene This article mentions the following:

When thiophene, 2-methylthiophene, 3-methylthiophene, 2,5-dimethylthiophene, benzothiophene and 2-methylbenzothiophene were brominated with N-bromosuccinimide, the products-2-bromothiophene, 2-bromo-5-methylthiophene, 2-bromo-3-methylthiophene, 3-bromo-2, 5-dimethylthiophene, 3-bromobenzothiophene and 3-bromo-2-methylbenzothiophene, resp., were obtained with high regioselectivity at high yield. Only mono-bromothiophene derivatives were produced without formation of dibromothiophene derivatives The brominated products were isolated very conveniently. Me radicals on thiophene derivatives had great influence on the rate of bromination. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9Application In Synthesis of 3-Bromo-2-methylbenzo[b]thiophene).

3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Application In Synthesis of 3-Bromo-2-methylbenzo[b]thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Discovery of Potent Irreversible Pan-Fibroblast Growth Factor Receptor (FGFR) Inhibitors was written by Wang, Yuming;Li, Lijun;Fan, Jun;Dai, Yang;Jiang, Alan;Geng, Meiyu;Ai, Jing;Duan, Wenhu. And the article was included in Journal of Medicinal Chemistry in 2018.Computed Properties of C9H8OS This article mentions the following:

Fibroblast growth factor receptors (FGFR1-4) are promising therapeutic targets in many cancers. With the resurgence of interest in irreversible inhibitors, efforts have been directed to the discovery of irreversible FGFR inhibitors. Currently, several selective irreversible inhibitors are being evaluated in clin. trials that could covalently target a conserved cysteine in the P-loop of FGFR. In this article, the authors used a structure-guided approach that is rationalized by a computer-aided simulation to discover the novel and irreversible pan-FGFR inhibitor, 9g ((S)-1-(3-(4-amino-5-(7-methoxy-5-methylbenzo[b]thien-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidin-1-yl)prop-2-en-1-one), which provided superior FGFR in vitro activities and decent selectivity over VEGFR2 (vascular endothelia growth factor receptor 2). In in vivo studies, 9g displayed clear antitumor activities in NCI-H1581 and SNU-16 xenograft mice models. Addnl., the diluting method confirmed the irreversible binding of 9g to FGFR. In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4Computed Properties of C9H8OS).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Computed Properties of C9H8OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Efficient synthesis of chiral 2,3-dihydro-benzo[b]thiophene 1,1-dioxides via Rh-catalyzed hydrogenation was written by Liu, Gongyi;Zhang, Heng;Huang, Yi;Han, Zhengyu;Liu, Gang;Liu, Yuanhua;Dong, Xiu-Qin;Zhang, Xumu. And the article was included in Chemical Science in 2019.Application of 10243-15-9 This article mentions the following:

Rh-catalyzed asym. hydrogenation of prochiral substituted benzo[b]thiophene 1,1-dioxides was successfully developed, affording various chiral 2,3-dihydrobenzo[b]thiophene 1,1-dioxides I (R = H, 6-MeO; R¹ = C₆H₅, 4-MeOC₆H₄, 4-FC₆H₄, etc.; R² = C₆H₅, 4-MeOC₆H₄, 3-H₃CC₆H₄, etc.) with high yields and excellent enantioselectivities (up to 99% yield and >99% ee). In particular, for challenging substrates, such as aryl substituted substrates with sterically hindered groups and alkyl substituted substrates, the reaction proceeded smoothly in catalytic system with excellent results. The gram-scale asym. hydrogenation proceeded well with 99% yield and 99% ee in the presence of 0.02 mol% (S/C = 5000) catalyst loading. The possible hydrogen-bonding interaction between the substrate and the ligand may play an important role in achieving high reactivity and excellent enantioselectivity. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9Application of 10243-15-9).

3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Application of 10243-15-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Regioselective synthesis of C3 alkylated and arylated benzothiophenes was written by Shrives, Harry J.;Fernandez-Salas, Jose A.;Hedtke, Christin;Pulis, Alexander P.;Procter, David J.. And the article was included in Nature Communications in 2017.COA of Formula: C9H5NS This article mentions the following:

The method for completely regioselective, metal-free C3 C-H functionalization of benzothiophenes e.g., I that utilizes synthetically unexplored benzothiophene S-oxides II (R¹ = H, 5-NO₂, 6-Br, etc.; R² = H, CO₂CH₃, CN, etc.), readily available from straightforward oxidation of benzothiophenes such as 5-bromobenzo[b]thiophene, 2-phenylbenzo[b]thiophene, 2-methylbenzo[b]thiophene, etc. and phenols such as p-cresol, 4-iodophenol, 4-nitrophenol, etc./propargyl silanes such as trimethyl(allyl)silane, trimethyl(2-bromoallyl)silane, 2-((trimethylsilyl)methyl)allyl acetate, etc. and allyl silanes such as propargyl silane, hex-1-yne-1,3-diylbis(trimethylsilane), hept-2-yn-1-yltrimethylsilane, etc. was described. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9COA of Formula: C9H5NS).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.COA of Formula: C9H5NS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Fischer Dinuclear and Mononuclear Bis-Carbene Complexes of Thiophene and Thiophene Derivatives was written by Lotz, Simon;van Jaarsveld, Nina A.;Liles, David C.;Crause, Chantelle;Gorls, Helmar;Terblans, Yvette M.. And the article was included in Organometallics in 2012.Product Details of 6287-82-7 This article mentions the following:

The reaction of dilithiated thiophene and thiophene derivatives with group 6 transition metal carbonyl precursors and subsequent alkylation afforded linearly arranged Fischer 2,5-bis-carbene and the rare unsym. 2,3-bis-carbene chelated complexes. The latter requires a second lithiation to occur at an adjacent, less reactive site on the thiophene ring. The control of reactivity sites was investigated and achieved by either blocking more reactive positions with substituents or activating less reactive positions by lithium-halogen exchange reactions. A series of Fischer bis-carbene chelates were synthesized by manipulating the above variables. Structural features of Fischer mono-carbene, mononuclear bis-carbene, and bis-carbene chelated complexes were studied by IR, NMR, and single-crystal x-ray diffraction. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Product Details of 6287-82-7).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Product Details of 6287-82-7

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem