Month: November 2022

Amine-functional polysiloxanes (AFPs) as efficient polymeric organocatalyst for amino catalysis: efficient multicomponent Gewald reaction, α-allylic alkylation of aldehydes, and Knoevenagel condensation was written by Zheng, Zhan-Jiang;Liu, Lu-Xin;Gao, Guang;Dong, Hong;Jiang, Jian-Xiong;Lai, Guo-Qiao;Xu, Li-Wen. And the article was included in RSC Advances in 2012.Safety of Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate The following contents are mentioned in the article:

In this article, for the first time, we describe that com. available and environmentally benign amine-functional polysiloxanes (AFPs) could be used as highly efficient metal-free amino catalysts in multicomponent Gewald reactions, α-allylic alkylations of aldehydes, and Knoevenagel condensations. Using catalytic amounts of AFPs, these transformations, including the Gewald reactions of ketones, sulfur, and Et 2-cyanoacetate, α-allylic alkylations of aldehydes and Knoevenagel condensations of aldehydes and the methylene-activated substrates may be carried out under mild conditions to give corresponding products in good yields. This study involved multiple reactions and reactants, such as Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9Safety of Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate).

Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Safety of Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Homolytic Aromatic Sulfonation with K₂S₂O₅ Promoted by a Combination of Mn(OAc)₃·2H₂O and HFIP was written by Han, Bingxu;Gu, Xin;Li, Ke;Qi, Yunkun;Liang, Shuai. And the article was included in Journal of Organic Chemistry in 2022.SDS of cas: 638-02-8 The following contents are mentioned in the article:

Herein, authors reported a so far unprecedented Mn(OAc)₃·2H₂O-promoted homolytic aromatic sulfonation. The reaction was performed under mild conditions with K₂S₂O₅ employed as a green sulfonating reagent. Various arenes were successfully converted into desired sulfonic acids or sulfonates in high efficiency. Preliminary mechanistic studies demonstrated that the present reaction proceeds via a homolytic aromatic substitution-type mechanism involving an SO₃^– radical. The combination of Mn(OAc)₃·2H₂O and HFIP plays a crucial role. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8SDS of cas: 638-02-8).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is also used in the manufacturing of dyes such as thioindigo.SDS of cas: 638-02-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Chiral acid-catalysed enantioselective C-H functionalization of toluene and its derivatives driven by visible light was written by Li, Fuyuan;Tian, Dong;Fan, Yifan;Lee, Richmond;Lu, Gang;Yin, Yanli;Qiao, Baokun;Zhao, Xiaowei;Xiao, Ziwei;Jiang, Zhiyong. And the article was included in Nature Communications in 2019.Category: benzothiophene The following contents are mentioned in the article:

Here, photoinduced radical-based enantioselective C(sp³)-C(sp³) coupling reactions of activated ketones with toluene and its derivatives by means of chiral acid catalysis was reported. With a La(OTf)₃/pybox complex catalyst, a variety of chiral 3-hydroxy-3-benzyl-substituted 2-oxindoles, including many conventionally difficult-to-access variants, are obtained directly from isatins in high yields with good to excellent enantioselectivities. Acenaphthoquinone is also compatible with the use of a chiral phosphoric acid (CPA) catalyst, leading to another series of important enantioenriched tertiary alcs. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Category: benzothiophene).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Category: benzothiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis and pharmacological activities of some 3-substituted thienopyrimidin-4-one-2-thiones was written by Cannito, A.;Perrissin, M.;Luu Duc, Cuong;Huguet, F.;Gaultier, C.;Narcisse, G.. And the article was included in European Journal of Medicinal Chemistry in 1990.COA of Formula: C12H17NO2S The following contents are mentioned in the article:

The condensation of substituted 2-amino-3-carbethoxythiophenes with Me, Et and Ph isothiocyanate yields the corresponding thienylthioureas which cyclize in EtOH saturated with dry hydrochloric acid to form 3-substituted thieno[2,3-d]pyrimidin-4(3H)-one-2-thiones. Thirty-five compounds, 21 thienylthioureas and 14 thienopyrimidin-4-one-2-thiones, have been screened for their analgesic and antiinflammatory activities. The i.p. administration of these products at a dose of 1000 mg/kg shows that they are not toxic (one excepted). Some compounds show analgesic and antiinflammatory activities equivalent to those of acetylsalicylic acid. This study involved multiple reactions and reactants, such as Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9COA of Formula: C12H17NO2S).

Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is also used in the manufacturing of dyes such as thioindigo.COA of Formula: C12H17NO2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Photo- and ionochromic thienyl(coumarinyl)thiazoles was written by Shepelenko, Evgenii N.;Podshibyakin, Vitaly A.;Tikhomirova, Karina S.;Revinskii, Yurii V.;Dubonosov, Alexander D.;Bren, Vladimir A.;Minkin, Vladimir I.. And the article was included in Journal of Molecular Structure in 2018.Name: 2,5-Dimethylthiophene The following contents are mentioned in the article:

Thienyl (6-methoxycoumarinyl)thiazoles containing various amino groups in bridging fragment were synthesized. In the ring-opened form, the dihetarylethenes display fluorescence with quantum yields of 0.012-0.015. Irradiation of their solutions with light of 365 or 436 nm results in the formation of non-fluorescent ring-closed isomers. Re-opening of the cyclohexadiene ring occurs under exposure to visible light (λ > 500 nm). The prepared compounds represent bifunctional chemosensors – “naked-eye” chromogenic for F^– anions (change of the solution color from yellow to brown-red) and fluorogenic for Hg²⁺ cations (with CHEQ effect). This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Name: 2,5-Dimethylthiophene).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Name: 2,5-Dimethylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Direct C-H Arylation of Heteroarenes with Copper Impregnated on Magnetite as a Reusable Catalyst: Evidence for CuO Nanoparticle Catalysis in Solution was written by Vasquez-Cespedes, Suhelen;Chepiga, Kathryn M.;Moeller, Nadja;Schaefer, Andreas H.;Glorius, Frank. And the article was included in ACS Catalysis in 2016.Safety of 2,5-Dimethylthiophene The following contents are mentioned in the article:

A reusable copper-based catalyst system was employed for the direct arylation of electron-rich heteroarenes. Under mild and operationally simple reaction conditions good yields and selectivities were obtained using diaryliodonium salts as coupling partners. A combination of exptl. methods including kinetic studies, filtration tests, and a series of anal. tools (TXRF, ICP-MS, SEM, XPS, TEM, EFTEM) provide evidence for catalytically active soluble nanoparticles formed from an amorphous heterogeneous precursor. Mechanistic studies hint at a redox-neutral process which promotes counterion dissociation from the diaryliodonium salt by a copper(II) oxide species. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Safety of 2,5-Dimethylthiophene).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Safety of 2,5-Dimethylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Superelectrophilic-Initiated C-H Functionalization at the β-Position of Thiophenes: A One-Pot Synthesis of trans-Stereospecific Saddle-Shaped Cyclic Compounds was written by Wei, Ying;Zheng, Xiangping;Lin, Dongqing;Yuan, Haoxuan;Yin, Zhipeng;Yang, Lei;Yu, Yang;Wang, Shasha;Xie, Ling-Hai;Huang, Wei. And the article was included in Journal of Organic Chemistry in 2019.Name: 2,5-Dimethylthiophene The following contents are mentioned in the article:

Superelectrophilic-initiated direct C-H functionalization of thiophenes at the β-position was developed. A series of trans-stereospecific [2,1-a]-IF-thiophene-fused cyclic compounds (4) with saddle-shaped structure were prepared in 17-30% yields through a one-pot superelectrophilic Friedel-Crafts reaction of dihydroindenofluorene with thiophene derivatives From the crystal packing analyses of 4a, its skeleton shows both strong intermol. π-π stacking and C-H···π stacking. Furthermore, the ring-dependent photophys. properties were confirmed by UV-vis absorption and photoluminescence spectroscopy as well as through the study of their fluorescence quantum yield. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Name: 2,5-Dimethylthiophene).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Name: 2,5-Dimethylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Catalytic, Interrupted Formal Homo-Nazarov Cyclization with (Hetero)arenes: Access to α-(Hetero)aryl Cyclohexanones was written by Williams, Corey W.;Shenje, Raynold;France, Stefan. And the article was included in Journal of Organic Chemistry in 2016.Quality Control of 2,5-Dimethylthiophene The following contents are mentioned in the article:

The first examples of a Lewis-acid catalyzed (hetero)arene interrupted, formal homo-Nazarov cyclization have been disclosed. Using SnCl₄ as the catalyst, alkenyl cyclopropyl ketones undergo ring-opening cyclization to form six-membered cyclic oxyallyl cations. Subsequent intermol. Friedel-Crafts-type arylation with various electron-rich arenes and heteroarenes provides functionalized α-(hetero)arylated cyclohexanones, a scaffold present in many natural products and bioactive compounds, in yields up to 88% and diastereomeric ratios up to 12:1. Regiospecific arylation occurs at the α-carbon of the oxyallyl cation due to polarization caused by the ester group. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Quality Control of 2,5-Dimethylthiophene).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Quality Control of 2,5-Dimethylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

The Photostability of Two Optical Materials Based on Perylene Diimide Substituted by Different Aromatic Groups at the Bay Area was written by He, Junjie;Li, Song;Zeng, Heping. And the article was included in Journal of Heterocyclic Chemistry in 2017.SDS of cas: 638-02-8 The following contents are mentioned in the article:

The perylene diimide substituted by thiophene rings at bay area shows photoactivity and can be used as a photo sensor, but another 1 substituted by mesitylene groups is photostable. The single crystal of 1,7-mesitylene perylenediimide was obtained. X-ray diffraction data of the crystal revealed that the plane of the perylene core was hardly twisted by introduction of mesitylene groups. These mesitylene groups are like clips maintaining the planarity of the perylene core. D. functional theory calculation was applied to study the difference of photophys. and photochem. properties. The discovery is valuable for design guidance of perylenediimides. Crystallog. data are given. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8SDS of cas: 638-02-8).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.SDS of cas: 638-02-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Pharmacologically active benzo[b]thiophene derivatives. III. 2-Substituted compounds was written by Chapman, Norman Bellamy;Clarke, Kenneth;Saraf, S. D.. And the article was included in Journal of the Chemical Society [Section] C: Organic in 1967.Application of 13771-68-1 The following contents are mentioned in the article:

cf. CA 62, 6450f; 65, 18549g. A number of N-(5-substituted-2-benzo[b]thenyl)ethanolamines (I) and the corresponding N-Me and N-Et derivatives were prepared by condensation of the 5-substituted 2-chloromethylbenzo[b]thiophenes with ethanolamine, N-methylethanolamine, or N-ethylethanolamine. These amino alcs. treated with SOCl2 in dry CHCl3 gave the corresponding β-chloroethylamines (II). 2-Acetyl-5-bromo- and -5-chlorobenzo[b]thiophene were prepared Bromination of these ketones, followed by condensation with several secondary amines, gave oxo amines, which were reduced with NaBH4 in aqueous MeOH to give corresponding amino alcs., some of which reacted with SOCl2 in dry CHCl3 as above. This study involved multiple reactions and reactants, such as Ethyl 5-bromobenzo[b]thiophene-2-carboxylate (cas: 13771-68-1Application of 13771-68-1).

Ethyl 5-bromobenzo[b]thiophene-2-carboxylate (cas: 13771-68-1) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Application of 13771-68-1

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem