Month: November 2022

Microwave-Assisted Syntheses of Thiophene-Based Ionic Liquids: Structural Design and Optimization was written by Schiel, Maria A.;Domini, Claudia E.;Chopa, Alicia B.;Silbestri, Gustavo F.. And the article was included in Synthesis in 2018.Product Details of 638-02-8 The following contents are mentioned in the article:

This manuscript explores microwave-assisted reactions for the synthesis of new ionic materials involving the S-alkylation of thiophene. All isolatable products have been fully characterized by NMR and all product have been quantified through UV-vis spectroscopy. By means of a design technique, the exptl. protocol (25 min, 200 W, 50 °C) has been optimized, which led us to better yields (96 %). In the absence of MW activation, the conventional thermal reaction at room temperature took longer (24 – 48 h) to obtain similar results. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Product Details of 638-02-8).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Product Details of 638-02-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Trametes versicolor (L.) mushrooms liquefaction in supercritical solvents: Effects of operating conditions on product yields and chromatographic characterization was written by Durak, Halil. And the article was included in Journal of Supercritical Fluids in 2018.Recommanded Product: 2,5-Dimethylthiophene The following contents are mentioned in the article:

In this study, the effect of reaction temperature, solvent and catalyst were examined on conversion of Trametes versicolor mushroom. Supercritical liquefaction experiments were made in a cylindrical reactor in acetone and isopropanol under supercritical circumstances with (Aluminum oxide, calcium hydroxide) and without catalyst at the temperatures of 250, 270, 290 ^°C. The bio-oils obtained at 250 and 290 °C in liquefaction were analyzed and characterized by chromatog. and spectroscopic techniques containing GC-MS, FT-IR and elemental anal. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Recommanded Product: 2,5-Dimethylthiophene).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Recommanded Product: 2,5-Dimethylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Densities at high pressures and derived properties of thiophenes was written by Anton, V.;Lomba, L.;Cea, P.;Giner, B.;Lafuente, C.. And the article was included in Journal of Chemical Thermodynamics in 2017.Electric Literature of C6H8S The following contents are mentioned in the article:

This contribution reports the densities in wide temperature (from 283.15 to 338.15 K) and pressure (from 0.1 to 65.0 MPa) ranges of four members of the thiophene family (thiophene, 2-methylthiophene, 3-methylthiophene and 2,5-dimethylthiophene). These densities have been satisfactorily correlated by means of the TRIDEN equation. From these data, several derived properties as isobaric expansibility, isothermal compressibility, and internal pressure have been estimated Using all these properties, interesting information about mol. organization can be deduced. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Electric Literature of C6H8S).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Electric Literature of C6H8S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Novel Small Molecule Inhibitors of MDR Mycobacterium tuberculosis by NMR Fragment Screening of Antigen 85C was written by Scheich, Christoph;Puetter, Vera;Schade, Markus. And the article was included in Journal of Medicinal Chemistry in 2010.Application In Synthesis of Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate The following contents are mentioned in the article:

Protein target-based discovery of novel antibiotics has been largely unsuccessful despite rich genome information. Particularly in need are new antibiotics for tuberculosis, which kills 1.6 million people annually and shows a rapid increase in multiple-drug-resistant cases. By combining fragment-based drug discovery with early whole cell antibacterial screening, we discovered novel ligand-efficient inhibitors of multiple-drug resistant Mycobacterium tuberculosis (Mtb), which bind to the substrate site of the Mtb protein antigen 85C, hitherto unused in Mtb chemotherapy. This study involved multiple reactions and reactants, such as Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9Application In Synthesis of Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate).

Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Application In Synthesis of Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Cu(I)-Induced Activation of Furan for Inverse Electron Demand ADAR with Alkenes toward Regioselective Synthesis of Tetrahydropyridine was written by Shukla, Prashant;Asati, Ambika;Bhardiya, Smita R.;Singh, Manorama;Rai, Vijai K.;Rai, Ankita. And the article was included in Journal of Organic Chemistry in 2020.Quality Control of 2,5-Dimethylthiophene The following contents are mentioned in the article:

The aza-Diels-Alder reaction of various alkenes and in situ formed 1-aza-1,3-dienes from the reaction of furan/pyrrole/thiophene and PhINTs for the regioselective synthesis of tetrahydropyridine (THP) derivatives was realized. The reaction was catalyzed by Tp^Me2Cu as a catalyst under very mild reaction conditions. Structurally different alkenes, along with an alkyne, have been utilized as dienophiles to afford a wide range of different THP derivatives up to 70% yield. The potential application of the envisaged method was also investigated by a gram-scale synthesis. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Quality Control of 2,5-Dimethylthiophene).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Quality Control of 2,5-Dimethylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Electrochemical Radical Selenylation of Alkenes and Arenes via Se-Se Bond Activation was written by Sun, Li;Wang, Liwei;Alhumade, Hesham;Yi, Hong;Cai, Hu;Lei, Aiwen. And the article was included in Organic Letters in 2021.Quality Control of 2,5-Dimethylthiophene The following contents are mentioned in the article:

A novel electrochem. radical selenylation of alkenes and activated arenes without external oxidants is reported. The diselenide was fully transformed into Se-centered radicals through electrochem. Se-Se bond activation. Three-component radical carbonselenation was successfully realized using styrenes to trap the RSe radical. Besides, the direct coupling of RSe radicals with activated arenes was further developed. Using this atom-economic protocol, diversity of unsym. aryl-aryl, aryl-alkyl, and alkyl-alkyl selenoethers was obtained regioselectively, which has potential application in biol. chem. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Quality Control of 2,5-Dimethylthiophene).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is also used in the manufacturing of dyes such as thioindigo.Quality Control of 2,5-Dimethylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Benzothiophene-flanked diketopyrrolopyrrole polymers: impact of isomeric frameworks on carrier mobilities was written by Huang, Jianyao;Liu, Xiaotong;Gao, Dong;Wei, Congyuan;Zhang, Weifeng;Yu, Gui. And the article was included in RSC Advances in 2016.Category: benzothiophene The following contents are mentioned in the article:

Exploring new building blocks for solution-processable polymeric semiconductors has attracted much attention. We herein develop two isomeric benzothiophene-flanked diketopyrrolopyrrole polymers with different linkage positions and further systematically study the electronic structures, optical properties, and field-effect characteristics. Both polymers exhibit typical p-type transport characteristics with the highest mobility being up to 0.80 cm² V^-1 s^-1. Our results suggest that the isomeric backbones for conjugated polymers greatly affect charge transport properties. This study involved multiple reactions and reactants, such as Ethyl 5-bromobenzo[b]thiophene-2-carboxylate (cas: 13771-68-1Category: benzothiophene).

Ethyl 5-bromobenzo[b]thiophene-2-carboxylate (cas: 13771-68-1) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Category: benzothiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Direct alkylation of thiophenes via bis-coupling with vinyl acetates was written by Zhang, Tong;Wang, Nai-Xing;Wu, Yue-Hua;Yan, Zhan;Xing, Yalan;Wen, Jia-Long;Gao, Xue-Wang. And the article was included in Tetrahedron Letters in 2018.Recommanded Product: 2,5-Dimethylthiophene The following contents are mentioned in the article:

A novel direct alkylation of thiophenes via bis-coupling with vinyl acetates has been developed. To the best of our knowledge, this represents the first report of the iron-catalyzed coupling of two thiophenes with vinyl groups. Utilizing earth-abundant, inexpensive, and non-toxic iron catalysts, this methodol. converts simple thiophenes to sym. dithienylethane derivatives I (R¹ = 5-Et, 5-Me, 5-Cl, etc.; R² = H, Me, (CH₂)₂COOH; R³ = H; R² = R³ = -(CH₂)₅-) under mild conditions in one step. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Recommanded Product: 2,5-Dimethylthiophene).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Recommanded Product: 2,5-Dimethylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Tris-NHC-propagated self-supported polymer-based Pd catalysts for heterogeneous C-H functionalization was written by Mandal, Tanmoy;Dutta, Tapas Kumar;Mohanty, Sunit;Choudhury, Joyanta. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2021.COA of Formula: C6H8S The following contents are mentioned in the article:

Three-dimensionally propagated imidazolium-containing mesoporous coordination polymer and organic polymer-based platforms were successfully exploited to develop single-site heterogenized Pd-NHC catalysts for oxidative arene/heteroarene C-H functionalization reactions. The catalysts were efficient in directed arene halogenation, and nondirected arene and heteroarene arylation reactions. High catalytic activity, excellent heterogeneity and recyclability were offered by these systems making them promising candidates in the area of heterogeneous C-H functionalization, where efficient catalysts are still scarce. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8COA of Formula: C6H8S).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is also used in the manufacturing of dyes such as thioindigo.COA of Formula: C6H8S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Regioselective Arene and Heteroarene Functionalization: N-Alkenoxypyridinium Salts as Electrophilic Alkylating Agents for the Synthesis of α-Aryl/α-Heteroaryl Ketones was written by Zhai, Rong L.;Xue, Yun S.;Liang, Ting;Mi, Jia J.;Xu, Zhou. And the article was included in Journal of Organic Chemistry in 2018.SDS of cas: 638-02-8 The following contents are mentioned in the article:

Gold-catalyzed regioselective Friedel-Crafts reactions of terminal alkynes with arenes and heteroarenes mediated an N-hydroxypyridinium salt (generated in situ from pyridine-N-oxide and triflimide) yielded 1-(hetero)aryl-2-alkanones. The Friedel-Crafts reactions occurred via alkenyloxypyridinium salts formed in situ from an N-hydroxypyridinium salt and the terminal alkynes. The mechanism of the reaction was studied using DFT calculations, isolation and reaction of a methylenedecyloxypyridinium salt, and determination of the deuterium kinetic isotope effect in Friedel-Crafts reactions with benzene and hexadeuterobenzene. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8SDS of cas: 638-02-8).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.SDS of cas: 638-02-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem