Month: November 2022

Preparation of 4-Diazoisoquinolin-3-ones via Dimroth Rearrangement and Their Extension to 4-Aryltetrahydroisoquinolin-3-ones was written by Li, Zhenmin;Chen, Junrong;Wu, Li;Ren, Anni;Lu, Ping;Wang, Yanguang. And the article was included in Organic Letters in 2020.HPLC of Formula: 638-02-8 The following contents are mentioned in the article:

4-Diazoisoquinolin-3-ones were prepared efficiently via TBAB-promoted rearrangement of 4-diazoisochroman-3-imines under mild reaction conditions. The resulted 4-diazoisoquinolin-3-ones could be conveniently applied for the synthesis of 4-aryltetrahydroisoquinolin-3-ones either by the TfOH-catalyzed reaction with electron-rich arenes or by the BF₃-promoted reaction with aryl aldehydes. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8HPLC of Formula: 638-02-8).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.HPLC of Formula: 638-02-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

A Simple Synthesis of Alkyl 2-Aminobenzo[b]thiophene-3-carboxylates via an Unexpected Dehydrogenation of Alkyl 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylates was written by Adib, Mehdi;Bayanati, Maryam;Soheilizad, Mehdi;Ghazvini, Helia Janatian;Tajbakhsh, Mahmood;Amanlou, Massoud. And the article was included in Synlett in 2014.Recommanded Product: 95211-67-9 The following contents are mentioned in the article:

A simple method for the preparation of alkyl 2-aminobenzo[b]thiophene-3-carboxylates is described. Alkyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylates, generated from the Gewald three-component reaction between cyclohexanones, alkyl cyanoacetates, and sulfur, undergo dehydrogenation in benzonitrile under an air atm. to afford alkyl 2-aminobenzo[b]thiophene-3-carboxylates in good to excellent yields. This study involved multiple reactions and reactants, such as Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9Recommanded Product: 95211-67-9).

Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Recommanded Product: 95211-67-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Aerobic Dimerization of Ethyl 4-Thienyl-3-ketobutanoate toward a Modifiable Photochromic Diarylethene Precursor was written by Lvov, Andrey G.;Milevsky, Nikita A.;Yanina, Anna M.;Kachala, Vadim V.;Shirinian, Valerii Z.. And the article was included in Organic Letters in 2017.Recommanded Product: 638-02-8 The following contents are mentioned in the article:

A unique chem. transformation, the base-induced aerobic dimerization of Et 4-(2,5-dimethylthiophen-3-yl)-3-ketobutanoate leading to photochromic diarylethene with a 4-hydroxy-4-methylcyclopent-2-ene-1-one as an ethene bridge, is described. This compound is easily subjected to various chem. modifications and can be used as a new diarylethene precursor to produce photoactive compounds with desired properties and functions. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Recommanded Product: 638-02-8).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Recommanded Product: 638-02-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Adducts of triangular silver(I) 3,5-bis(trifluoromethyl)pyrazolate with thiophene derivatives: a weak interaction model of desulfurization was written by Liu, Rongrong;Zhang, Wenhua;Wei, Donghui;Chen, Jing-Huo;Ng, Seik Weng;Yang, Guang. And the article was included in Dalton Transactions in 2019.Formula: C6H8S The following contents are mentioned in the article:

π-Acidic triangular silver(I) 3,5-bis(trifluoromethyl)pyrazolate (Ag₃pz₃) can form 1:1 adducts with dibenzothiophene (DBT), 4,6-dimethyldibenzothiophene (DMDBT), benzothiophene (BT), and 2,5-dimethylthiophene (DMT), which are stabilized by weak Ag···S and Ag···C contacts and sometimes by π-π stacking and, therefore, may represent a weak interaction model for some adsorptive desulfurization processes. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Formula: C6H8S).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Formula: C6H8S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

An efficient aromatization of 2-amino-4,5,6,7-tetrahydrobenzo-[b]thiophene-3-carboxylates in dimethyl sulfoxide catalyzed by p-toluenesulfonic acid was written by Adib, Mehdi;Soheilizad, Mehd;Rajai-daryasaraei, Saideh;Mirzaei, Peiman. And the article was included in Synlett in 2015.Application In Synthesis of Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate The following contents are mentioned in the article:

An oxidation-aromatization of alkyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylates, is reported. The Gewald product, obtained from three-component condensation reaction between a cyclohexanone, an alkyl cyanoacetate, and sulfur, underwent an oxidation reaction in DMSO in the presence of a catalytic amount of p-toluenesulfonic acid to give the corresponding alkyl 2-aminobenzo[b]thiophene-3-carboxylate, e.g., I, in excellent yield. This study involved multiple reactions and reactants, such as Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9Application In Synthesis of Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate).

Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Application In Synthesis of Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Transition-Metal-Free Arylation and Alkylation of Diarylmethyl p-Tolyl Sulfones with Zinc Reagents was written by Miao, Maozhong;Yin, Wenguang;Wang, Lei;Chen, Zhengkai;Xu, Jianfeng;Ren, Hongjun. And the article was included in Journal of Organic Chemistry in 2018.Reference of 638-02-8 The following contents are mentioned in the article:

The transition-metal-free synthesis of unsym. and highly functionalized triarylmethanes, e.g. I, through arylation of the situ generated o-QMs from diarylmethyl p-tolyl sulfones with aryl zinc reagents is described. Alkyl zinc reagents are also well tolerated in this reaction. Addnl., the straightforward synthesis of the analog of the antituberculosis agent A and the key precursor of the anti-breast-cancer agent B are achieved by this strategy. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Reference of 638-02-8).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Reference of 638-02-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Proton magnetic resonance spectra of some benzo[b]thiophene derivatives was written by Chapman, Norman Bellamy;Ewing, David F.;Scrowston, R. M.;Westwood, R.. And the article was included in Journal of the Chemical Society [Section] C: Organic in 1968.Computed Properties of C11H9BrO2S The following contents are mentioned in the article:

Attempts are made to correlate the chem. shifts in the 100 Mc./sec. 1H N.M.R. spectra of 42 benzo[b]thiophene derivatives with the substituents present in the mol., and the relations are rationalized where possible. Coupling constants are also recorded, and their dependence on bond order and on other factors is discussed. The changes in the chem. shifts and coupling constants when the benzo[b]thiophenes are oxidized to the 1,1-dioxides are recorded and discussed. 43 references. This study involved multiple reactions and reactants, such as Ethyl 5-bromobenzo[b]thiophene-2-carboxylate (cas: 13771-68-1Computed Properties of C11H9BrO2S).

Ethyl 5-bromobenzo[b]thiophene-2-carboxylate (cas: 13771-68-1) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is also used in the manufacturing of dyes such as thioindigo.Computed Properties of C11H9BrO2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Transition-Metal-Free Intermolecular α-Arylation of Ketones via Enolonium Species was written by Maksymenko, Shimon;Parida, Keshaba N.;Pathe, Gulab K.;More, Atul A.;Lipisa, Yuriy B.;Szpilman, Alex M.. And the article was included in Organic Letters in 2017.SDS of cas: 638-02-8 The following contents are mentioned in the article:

Herein it is shown, for the first time, that enolonium species are powerful electrophiles capable of reacting with aromatic compounds in an intermol. manner to afford α-arylated ketones. The reaction is compatible with a variety of functional groups, is of wide scope with respect to aromatic compounds and ketone, and even works for polymerization-prone substrates such as substituted pyrroles, thiophenes, and furans. Only 1.6 to 5 equiv of the commodity aromatic substrates is needed. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8SDS of cas: 638-02-8).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is also used in the manufacturing of dyes such as thioindigo.SDS of cas: 638-02-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

AIBN-initiated direct thiocyanation of benzylic sp³ C-H with N-thiocyanatosaccharin was written by Wu, Di;Duan, Yongjie;Liang, Kun;Yin, Hongquan;Chen, Fu-Xue. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2021.Computed Properties of C6H8S The following contents are mentioned in the article:

A new strategy, involving a free radical reaction pathway initiated by AIBN, was used to construct the benzylic sp³ C-SCN bond. In this way, the disadvantage of other strategies involving introducing leaving groups in advance to synthesize benzyl thiocyanate compounds was avoided. The currently developed protocol also involved the use of readily available raw materials and resulted in high product yields (up to 100%), both being great advantages for synthesizing benzyl thiocyanates. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Computed Properties of C6H8S).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Computed Properties of C6H8S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Structure-activity relationship study of novel tissue transglutaminase inhibitors was written by Duval, Eric;Case, April;Stein, Ross L.;Cuny, Gregory D.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Recommanded Product: 95211-67-9 The following contents are mentioned in the article:

Thieno[2,3-d]pyrimidin-4-one acyl hydrazide derivatives, e.g., I, were discovered as moderately potent inhibitors of TGase 2 (tissue transglutaminase) utilizing a fluorescence-based assay that measured TGase 2 catalyzed incorporation of the dansylated Lys derivative α-N-Boc-Lys-CH₂-CH₂-dansyl into the protein substrate N,N-dimethylated-casein. A SAR study revealed that the acyl hydrazide thioether side-chain and the thiophene ring were critical to inhibitory activity. This study involved multiple reactions and reactants, such as Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9Recommanded Product: 95211-67-9).

Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Recommanded Product: 95211-67-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem