Regioselective Arene and Heteroarene Functionalization: N-Alkenoxypyridinium Salts as Electrophilic Alkylating Agents for the Synthesis of α-Aryl/α-Heteroaryl Ketones was written by Zhai, Rong L.;Xue, Yun S.;Liang, Ting;Mi, Jia J.;Xu, Zhou. And the article was included in Journal of Organic Chemistry in 2018.SDS of cas: 638-02-8 The following contents are mentioned in the article:
Gold-catalyzed regioselective Friedel-Crafts reactions of terminal alkynes with arenes and heteroarenes mediated an N-hydroxypyridinium salt (generated in situ from pyridine-N-oxide and triflimide) yielded 1-(hetero)aryl-2-alkanones. The Friedel-Crafts reactions occurred via alkenyloxypyridinium salts formed in situ from an N-hydroxypyridinium salt and the terminal alkynes. The mechanism of the reaction was studied using DFT calculations, isolation and reaction of a methylenedecyloxypyridinium salt, and determination of the deuterium kinetic isotope effect in Friedel-Crafts reactions with benzene and hexadeuterobenzene. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8SDS of cas: 638-02-8).
2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.SDS of cas: 638-02-8
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem