Catalytic, Interrupted Formal Homo-Nazarov Cyclization with (Hetero)arenes: Access to α-(Hetero)aryl Cyclohexanones was written by Williams, Corey W.;Shenje, Raynold;France, Stefan. And the article was included in Journal of Organic Chemistry in 2016.Quality Control of 2,5-Dimethylthiophene The following contents are mentioned in the article:
The first examples of a Lewis-acid catalyzed (hetero)arene interrupted, formal homo-Nazarov cyclization have been disclosed. Using SnCl4 as the catalyst, alkenyl cyclopropyl ketones undergo ring-opening cyclization to form six-membered cyclic oxyallyl cations. Subsequent intermol. Friedel-Crafts-type arylation with various electron-rich arenes and heteroarenes provides functionalized α-(hetero)arylated cyclohexanones, a scaffold present in many natural products and bioactive compounds, in yields up to 88% and diastereomeric ratios up to 12:1. Regiospecific arylation occurs at the α-carbon of the oxyallyl cation due to polarization caused by the ester group. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Quality Control of 2,5-Dimethylthiophene).
2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Quality Control of 2,5-Dimethylthiophene
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem