Synthesis and SAR of thiophene containing kinesin spindle protein (KSP) inhibitors was written by Pinkerton, Anthony B.;Lee, Tom T.;Hoffman, Timothy Z.;Wang, Yan;Kahraman, Mehmet;Cook, Travis G.;Severance, Daniel;Gahman, Timothy C.;Noble, Stewart A.;Shiau, Andrew K.;Davis, Robert L.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Recommanded Product: 95211-67-9 The following contents are mentioned in the article:
A series of thiophene-containing inhibitors of kinesin spindle protein (KSP) I [R1 = H, Me; R12 = (CH2)4, CH2CMe2CH2CH2, CH2OCH2CH2, etc.; R2 = Ph, 2-thienyl, 2-furyl, 1,3-thiazol-5-yl, etc.; R3 = R4 = H, Me, Et; R3R4 = (CH2)3, (CH2)4, etc.; R3 = H, Me, R4 = Me2NCH2CH2] was identified and synthesized. SAR studies led to the synthesis of I (R12 = CH2CH2CHMeCH2; R2 = 2-thienyl; R3 = R4 = Et), which was co-crystallized with KSP and determined to bind to an allosteric pocket previously described for other known KSP inhibitors. This study involved multiple reactions and reactants, such as Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9Recommanded Product: 95211-67-9).
Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Recommanded Product: 95211-67-9
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem