Synthesis and pharmacological activities of some substituted thienopyrimidine-4-ones was written by Perrissin, Monique;Favre, Marylene;Cuong Luu Duc;Huguet, Francois;Gaultier, Chantal;Narcisse, Guy. And the article was included in European Journal of Medicinal Chemistry in 1988.Recommanded Product: 95211-67-9 The following contents are mentioned in the article:
Thieno[2,3-d]pyrimidin-4-ones I [RR1 = (CH2)3, (CH2)4, CH2CHMeCH2CH2, CH2CH2CHMeCH2, CHMe(CH2)3, (CH2)5; R = H, R1 = Ph; R2 = Me, CH2Ph] were prepared by acylating the aminothiophenes II, followed by cyclization with N2H4. Thienopyrimidinones III were obtained from II and 3-CF3C6H4CN. Analgesic and anti-inflammatory properties of these 18 compounds were investigated. Most of them showed very low toxicity. Seven compounds exhibited significant analgesic activity, six compounds displayed an anti-inflammatory activity. Some possessed both effects at levels close to those exhibited by acetylsalicylic acid. This study involved multiple reactions and reactants, such as Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9Recommanded Product: 95211-67-9).
Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Recommanded Product: 95211-67-9
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem