Thieno[2.3-d]-4-pyrimidones: synthesis, structure and pharmacological properties was written by Perrissin, Monique;Favre, Marylene;Luu-Duc, Cuong;Bakri-Logeais, Francoise;Huguet, Francois;Narcisse, Guy. And the article was included in European Journal of Medicinal Chemistry in 1984.Safety of Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate The following contents are mentioned in the article:
The cyclization of 2-aminothiophenes I [R = CO2Et; R1 = Ph, R2 = H; R1R2 = (CH2)3, (CH2)4, CHMe(CH2)3, CH2CHMeCH2CH2, CH2CH2CHMeCH2, (CH2)5] with HCONH2 or PhCN yields 4-pyrimidones II (R3 = H, Ph). Similar reaction of I (R = CONH2) with (MeCO)2CH2 gave II (R3 = Me). Their structure and their lactam-lactim tautomerism were investigated by IR spectroscopy. Ten II have analgesic activity equal or superior to that of aspirin. Only II [R1R2 = (CH2)3, CH2CHMeCH2CH2, R3 = H] have some antiinflammatory activity. This study involved multiple reactions and reactants, such as Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9Safety of Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate).
Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Safety of Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem