Transition-Metal-Free Arylation and Alkylation of Diarylmethyl p-Tolyl Sulfones with Zinc Reagents was written by Miao, Maozhong;Yin, Wenguang;Wang, Lei;Chen, Zhengkai;Xu, Jianfeng;Ren, Hongjun. And the article was included in Journal of Organic Chemistry in 2018.Reference of 638-02-8 The following contents are mentioned in the article:
The transition-metal-free synthesis of unsym. and highly functionalized triarylmethanes, e.g. I, through arylation of the situ generated o-QMs from diarylmethyl p-tolyl sulfones with aryl zinc reagents is described. Alkyl zinc reagents are also well tolerated in this reaction. Addnl., the straightforward synthesis of the analog of the antituberculosis agent A and the key precursor of the anti-breast-cancer agent B are achieved by this strategy. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Reference of 638-02-8).
2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Reference of 638-02-8
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem