Synthesis, Cytotoxic Activity and Molecular Docking Studies of New Condensed Thieno[2,3-d]Pyrimidines as Antitumor Agents was written by Kaliraj, S.;Jeyalakshmi, R.;Kathiravan, M. K.. And the article was included in Pharmaceutical Chemistry Journal in 2020.Reference of 95211-67-9 The following contents are mentioned in the article:
A series of lactam fused thienopyrimidines I [R1 = H, Me, Et, CO2Me, etc.; R2 = H, Me; R1R2 = (CH2)4, (CH2)3CH(Me); n = 1, 2, 3] and triazole fused thienopyrimidines II [R1 = H, Me, CO2Et, etc.; R2 = H, Me, Ph; R3 = Me, 4-OHC6H4; R1R2 = (CH2)3, (CH2)4, (CH2)3CH(Me)] were synthesized. The target compounds were obtained in good yield and confirmed for their structural integrity. The cytotoxic activity against A431 human epidermoid carcinoma and H9c2 rat cardiomyocyte cells were studied by MTT assay. Most of the synthesized compounds showed 85% cell death in both human A341 and rat H9c2 cell lines, indicating potential anticancer activity of these compounds Interestingly, compound II [R3 = 4-OHC6H4] showed a reversal in trend by enhancing the growth of both A341 and H9c2 cells. This study involved multiple reactions and reactants, such as Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9Reference of 95211-67-9).
Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Reference of 95211-67-9
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem