Structure-activity relationship study of novel tissue transglutaminase inhibitors was written by Duval, Eric;Case, April;Stein, Ross L.;Cuny, Gregory D.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Recommanded Product: 95211-67-9 The following contents are mentioned in the article:
Thieno[2,3-d]pyrimidin-4-one acyl hydrazide derivatives, e.g., I, were discovered as moderately potent inhibitors of TGase 2 (tissue transglutaminase) utilizing a fluorescence-based assay that measured TGase 2 catalyzed incorporation of the dansylated Lys derivative α-N-Boc-Lys-CH2-CH2-dansyl into the protein substrate N,N-dimethylated-casein. A SAR study revealed that the acyl hydrazide thioether side-chain and the thiophene ring were critical to inhibitory activity. This study involved multiple reactions and reactants, such as Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9Recommanded Product: 95211-67-9).
Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Recommanded Product: 95211-67-9
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem