A solvent less synthesis of 2-aminothiophenes via the Gewald reaction under ultrasonic conditions was written by de C. F. dos Santos, Bruno Dias;Forero, Josue S. Bello;de Carvalho, Erika M.;Jones, Joel Jr.;da Silva, Flavia M.. And the article was included in Heterocyclic Letters in 2012.Category: benzothiophene The following contents are mentioned in the article:
A simple, fast and efficient one-pot, three-component, solvent less procedure for the synthesis of 2-aminothiophene derivatives under ultrasonic conditions was developed. The combined advantages of sonochem., such as mild reaction conditions, good yield and short reaction times, enabled progress to be made on the synthesis of 2-aminothiophenes via the Gewald reaction. This study involved multiple reactions and reactants, such as Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9Category: benzothiophene).
Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Category: benzothiophene
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem