Pharmacologically active benzo[b]thiophene derivatives. III. 2-Substituted compounds was written by Chapman, Norman Bellamy;Clarke, Kenneth;Saraf, S. D.. And the article was included in Journal of the Chemical Society [Section] C: Organic in 1967.Application of 13771-68-1 The following contents are mentioned in the article:
cf. CA 62, 6450f; 65, 18549g. A number of N-(5-substituted-2-benzo[b]thenyl)ethanolamines (I) and the corresponding N-Me and N-Et derivatives were prepared by condensation of the 5-substituted 2-chloromethylbenzo[b]thiophenes with ethanolamine, N-methylethanolamine, or N-ethylethanolamine. These amino alcs. treated with SOCl2 in dry CHCl3 gave the corresponding β-chloroethylamines (II). 2-Acetyl-5-bromo- and -5-chlorobenzo[b]thiophene were prepared Bromination of these ketones, followed by condensation with several secondary amines, gave oxo amines, which were reduced with NaBH4 in aqueous MeOH to give corresponding amino alcs., some of which reacted with SOCl2 in dry CHCl3 as above. This study involved multiple reactions and reactants, such as Ethyl 5-bromobenzo[b]thiophene-2-carboxylate (cas: 13771-68-1Application of 13771-68-1).
Ethyl 5-bromobenzo[b]thiophene-2-carboxylate (cas: 13771-68-1) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Application of 13771-68-1
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem